milan_criteria_liver_transplant: Milan Criteria for Liver Transplantation

In cliot: Clinical Indices and Outcomes Tools

Milan Criteria for Liver Transplantation

Description

Determines eligibility for liver transplantation in patients with cirrhosis and hepatocellular carcinoma (HCC) based on the Milan Criteria. These criteria identify patients with small, unresectable HCCs who are likely to have good post-transplant outcomes.

Usage

milan_criteria_liver_transplant(num_tumors, max_tumor_size_cm,
                                extra_hepatic_spread, vascular_invasion)

Arguments

num_tumors	Numeric. Total number of tumor nodules.
max_tumor_size_cm	Numeric. Diameter of the largest tumor nodule in centimeters.
extra_hepatic_spread	Numeric (0 or 1). Presence of extra-hepatic manifestations (metastases). (1 = Yes).
vascular_invasion	Numeric (0 or 1). Presence of macrovascular invasion. (1 = Yes).

Value

A list containing:

Result	Eligibility status ("Eligible" or "Not Eligible").
Explanation	The specific rule component that determined the result.

References

Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334(11):693-699. doi:10.1056/NEJM199603143341104

Examples

# Example 1: Eligible (Single small tumor)
# 1 tumor, 4.5 cm, No spread/invasion
milan_criteria_liver_transplant(1, 4.5, 0, 0)

# Example 2: Not Eligible (Too large)
# 2 tumors, largest 4.0 cm (Limit for multiple is 3 cm)
milan_criteria_liver_transplant(2, 4.0, 0, 0)

# Example 3: Eligible (Multiple small tumors)
# 3 tumors, largest 2.8 cm
milan_criteria_liver_transplant(3, 2.8, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.