mipss70_score: Mutation-Enhanced International Prognostic Score System...

In cliot: Clinical Indices and Outcomes Tools

Mutation-Enhanced International Prognostic Score System (MIPSS70 and MIPSS70+) for Primary Myelofibrosis

Description

Calculates the MIPSS70 and MIPSS70+ scores for risk stratification in patients with Primary Myelofibrosis (PMF) aged <= 70 years. The score integrates clinical risk factors, fibrosis grade, and mutational status (CALR, ASXL1, EZH2, SRSF2, IDH1/2). The MIPSS70+ version includes cytogenetic data.

Usage

mipss70_score(hemoglobin_g_l, wbc_x10_9_l, platelets_x10_9_l, blasts_percent,
              fibrosis_grade_ge_2, constitutional_symptoms, calr_type1_absent,
              hmr_mutation_count, karyotype_unfavorable = NULL)

Arguments

hemoglobin_g_l	Numeric. Hemoglobin level in g/L. (< 100 g/L adds 1 point).
wbc_x10_9_l	Numeric. White Blood Cell count in 10^9/L. (> 25 x 10^9/L adds 2 points).
platelets_x10_9_l	Numeric. Platelet count in 10^9/L. (< 100 x 10^9/L adds 2 points).
blasts_percent	Numeric. Percentage of circulating blasts. (>= 2% adds 1 point).
fibrosis_grade_ge_2	Numeric (0 or 1). Is bone marrow fibrosis grade >= 2? (1 = Yes, +1 point).
constitutional_symptoms	Numeric (0 or 1). Presence of constitutional symptoms (fever, weight loss, night sweats). (1 = Yes, +1 point).
calr_type1_absent	Numeric (0 or 1). Absence of CALR type 1 mutation. (1 = Yes, +1 point).
hmr_mutation_count	Numeric. Count of High Molecular Risk (HMR) mutations present (ASXL1, EZH2, SRSF2, IDH1, IDH2). 0: 0 pts. 1: 1 pt. >=2: 2 pts.
karyotype_unfavorable	Numeric (0 or 1) (Optional). Presence of unfavorable karyotype (e.g., complex karyotype, sole or two abnormalities including +8, -7/7q-, i(17q), inv(3), 5q-, 12p-, 11q23 rearrangement). If provided, calculates MIPSS70+ score. (1 = Yes, +3 points).

Value

A list containing:

MIPSS70_Score	The calculated score based on clinical and molecular factors.
MIPSS70_Risk_Category	Risk group (Low, Intermediate, High).
MIPSS70_Plus	A list containing the MIPSS70+ Score and Risk Category if karyotype data was provided.

References

Tefferi A, Guglielmelli P, Lasho TL, et al. MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis. J Clin Oncol. 2018;36(4):310-318. doi:10.1200/JCO.2017.76.4886

Examples

# Example 1: MIPSS70 High Risk
# Hb 90 (+1), WBC 30 (+2), HMR 2 (+2)
mipss70_score(90, 30, 150, 0, 0, 0, 0, 2)

# Example 2: MIPSS70+ Very High Risk
# Hb 110, Plt 80 (+2), Fibrosis 2 (+1), Unfavorable Karyotype (+3)
mipss70_score(110, 10, 80, 0, 1, 0, 0, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.