modified_asthma_predictive_index: Modified Asthma Predictive Index (mAPI)

In cliot: Clinical Indices and Outcomes Tools

Modified Asthma Predictive Index (mAPI)

Description

Calculates the Modified Asthma Predictive Index (mAPI) for young children (<= 3 years) with frequent wheezing. A positive mAPI predicts a high likelihood of developing asthma by school age. The index requires frequent wheezing (>3 episodes/year) plus either 1 Major criterion or 2 Minor criteria.

Usage

modified_asthma_predictive_index(age, wheezing_episodes_gt_3_per_year,
                                 parental_asthma, eczema, aeroallergen_sensitization,
                                 food_sensitization, wheezing_apart_from_colds,
                                 eosinophilia_gt_4_percent)

Arguments

age	Numeric. Age of the child in years. (Tool is validated for young children, typically <= 3).
wheezing_episodes_gt_3_per_year	Numeric (0 or 1). Does the child have >3 episodes of wheezing per year? (1 = Yes). This is a prerequisite for a positive score.
parental_asthma	Numeric (0 or 1). Parent with physician-diagnosed asthma. (Major Criterion).
eczema	Numeric (0 or 1). Physician-diagnosed atopic dermatitis (eczema). (Major Criterion).
aeroallergen_sensitization	Numeric (0 or 1). Sensitization to at least one aeroallergen (positive skin prick test or specific IgE). (Major Criterion).
food_sensitization	Numeric (0 or 1). Sensitization to milk, eggs, or peanuts. (Minor Criterion).
wheezing_apart_from_colds	Numeric (0 or 1). Wheezing apart from colds. (Minor Criterion).
eosinophilia_gt_4_percent	Numeric (0 or 1). Peripheral blood eosinophilia >= 4%. (Minor Criterion).

Value

A list containing:

mAPI_Result	"Positive mAPI" or "Negative mAPI".
Prediction	Prognostic interpretation regarding future asthma development.
Criteria_Met	Summary of major and minor criteria counts.

References

Guilbert TW, Morgan WJ, Zeiger RS, et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol. 2004;114(6):1282-1287. doi:10.1016/j.jaci.2004.09.020 Chang TS, Lemanske RF Jr, Guilbert TW, et al. Evaluation of the modified asthma predictive index in high-risk preschool children. J Allergy Clin Immunol Pract. 2013;1(2):152-156. doi:10.1016/j.jaip.2012.10.008

Examples

# Example 1: Positive mAPI
# Frequent wheezing (1), Eczema (1 Major), Eosinophilia
#(1 Minor - insufficient alone, but 1 major is enough)
# Result: Positive
modified_asthma_predictive_index(2, 1, 0, 1, 0, 0, 0, 1)

# Example 2: Negative mAPI
# Frequent wheezing (1), Only 1 Minor (Eosinophilia)
# Result: Negative
modified_asthma_predictive_index(3, 1, 0, 0, 0, 0, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.