nrpe_diuretic_response: Natriuretic Response Prediction Equation (NRPE)

In cliot: Clinical Indices and Outcomes Tools

Natriuretic Response Prediction Equation (NRPE)

Description

Calculates the predicted 6-hour cumulative sodium output based on a single spot urine sodium sample taken 2 hours after loop diuretic administration. This tool helps evaluate diuretic resistance and guide titration in patients with acute heart failure.

Usage

nrpe_diuretic_response(spot_urine_sodium)

Arguments

spot_urine_sodium

Numeric. Spot urine sodium concentration (mmol/L or mEq/L) measured 2 hours after diuretic administration.

Value

A list containing:

Predicted_6hr_Sodium_Output_mmol	The estimated total sodium excretion over 6 hours.
Interpretation	Assessment of response adequacy based on the common threshold of 50 mmol/L.

References

Rao VS, Ivey-Miranda JB, Cox ZL, et al. Natriuretic Equation to Predict Loop Diuretic Response in Patients With Heart Failure. J Am Coll Cardiol. 2019;74(7):861-868. doi:10.1016/j.jacc.2019.06.028

Examples

# Example 1: Poor Response
# Spot Na 30 mmol/L
nrpe_diuretic_response(30)

# Example 2: Good Response
# Spot Na 100 mmol/L
nrpe_diuretic_response(100)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.