pascal_classification_pfo: PFO-Associated Stroke Causal Likelihood (PASCAL)...

In cliot: Clinical Indices and Outcomes Tools

PFO-Associated Stroke Causal Likelihood (PASCAL) Classification

Description

Calculates the PASCAL classification to estimate the causal likelihood of a Patent Foramen Ovale (PFO) in a patient with cryptogenic stroke. This system integrates the RoPE Score with high-risk PFO anatomical features (large shunt or atrial septal aneurysm) to categorize the stroke-PFO relationship as Unlikely, Possible, or Probable.

Usage

pascal_classification_pfo(rope_score, high_risk_pfo_features)

Arguments

rope_score	Numeric. The Risk of Paradoxical Embolism (RoPE) score (0-10).
high_risk_pfo_features	Numeric (0 or 1). Presence of high-risk PFO features, defined as a large shunt or an atrial septal aneurysm (ASA). (1 = Yes).

Value

A list containing:

PASCAL_Classification

The causal likelihood category (Unlikely, Possible, Probable).

References

Kent DM, Saver JL, Kasner SE, et al. Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke. JAMA. 2021;326(22):2277–2286. doi:10.1001/jama.2021.20956

Examples

# Example 1: Probable (High RoPE + High Risk PFO)
pascal_classification_pfo(8, 1)

# Example 2: Possible (Low RoPE + High Risk PFO)
pascal_classification_pfo(4, 1)

# Example 3: Unlikely (Low RoPE + No High Risk Features)
pascal_classification_pfo(3, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.