paxlovid_eligibility_check: Indications for Paxlovid Prescribing

In cliot: Clinical Indices and Outcomes Tools

Indications for Paxlovid Prescribing

Description

Determines eligibility and appropriate dosing for Paxlovid (nirmatrelvir/ritonavir) therapy in patients with mild-to-moderate COVID-19. The function evaluates inclusion criteria (age, weight, risk factors, timing) and exclusion criteria (renal/hepatic impairment, drug interactions) based on FDA Emergency Use Authorization guidelines.

Usage

paxlovid_eligibility_check(covid_positive, symptom_onset_days, age_years,
                           weight_kg, has_risk_factors, egfr_ml_min,
                           severe_hepatic_impairment, significant_drug_interactions)

Arguments

covid_positive	Numeric (0 or 1). Confirmed positive SARS-CoV-2 test. (1 = Yes).
symptom_onset_days	Numeric. Days since symptom onset. (Must be <= 5 days for eligibility).
age_years	Numeric. Patient age in years. (Must be >= 12 for eligibility).
weight_kg	Numeric. Patient weight in kilograms. (Must be >= 40 kg for eligibility).
has_risk_factors	Numeric (0 or 1). Does the patient have one or more risk factors for progression to severe COVID-19 (e.g., age >= 50, cancer, diabetes, obesity, cardiovascular disease)? (1 = Yes).
egfr_ml_min	Numeric. Estimated Glomerular Filtration Rate (mL/min). Used for dosing adjustment. (<30 is contraindicated).
severe_hepatic_impairment	Numeric (0 or 1). Presence of severe hepatic impairment (Child-Pugh Class C). (1 = Yes).
significant_drug_interactions	Numeric (0 or 1). Use of medications that are highly dependent on CYP3A for clearance or are potent CYP3A inducers, where interactions cannot be managed. (1 = Yes).

Value

A list containing:

Status	"Eligible" or "Not Eligible / Contraindicated".
Recommendation	Specific dosing instructions (Standard vs. Renal dose) or "None".
Reason_for_Ineligibility	Explanation if the patient is not eligible.

References

FDA Fact Sheet for Healthcare Providers: Emergency Use Authorization for Paxlovid. U.S. Food and Drug Administration.

Examples

# Example 1: Eligible Standard Dose
# Positive, Day 3, 50yo, 80kg, Risk Factors, eGFR 90, No issues
paxlovid_eligibility_check(1, 3, 50, 80, 1, 90, 0, 0)

# Example 2: Eligible Renal Dose
# Positive, Day 4, 65yo, 70kg, Risk Factors, eGFR 45, No issues
paxlovid_eligibility_check(1, 4, 65, 70, 1, 45, 0, 0)

# Example 3: Contraindicated (eGFR)
# Positive, Day 2, 70yo, 70kg, Risk Factors, eGFR 20
paxlovid_eligibility_check(1, 2, 70, 70, 1, 20, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.