pbsc_collection_volume: Peripheral Blood Stem Cell (PBSC) Collection Volume...

In cliot: Clinical Indices and Outcomes Tools

Peripheral Blood Stem Cell (PBSC) Collection Volume Calculator

Description

Calculates the total blood volume (in Liters) that must be processed through an apheresis machine to achieve a specific target yield of CD34+ stem cells. The calculation is based on the patient's weight, the pre-apheresis peripheral CD34+ cell count, and the estimated collection efficiency of the machine.

Usage

pbsc_collection_volume(weight_kg, pre_cd34_count, target_yield,
                       collection_efficiency_percent = 50)

Arguments

weight_kg	Numeric. Patient weight in kilograms.
pre_cd34_count	Numeric. Peripheral blood CD34+ cell count (cells/uL or cells/mm^3).
target_yield	Numeric. The desired CD34+ cell yield in millions of cells per kg (x 10^6/kg). Common targets range from 2 to 5 x 10^6/kg.
collection_efficiency_percent	Numeric. The estimated efficiency of the apheresis machine in collecting CD34+ cells (0-100). Defaults to 50%. Standard range is typically 30-50%.

Details

The formula used is:

Volume (L) = \frac{Target Yield \times Weight}{CD34_{pre} \times Efficiency}

Where:

• Target Yield is in 10^6 cells/kg

• CD34_{pre} is in cells/\muL

• Efficiency is a decimal (Percent/100)

Note: The units cancel out such that the result is directly in Liters.

Value

A list containing:

Volume_to_Process_Liters

The estimated blood volume to process to reach the target yield.

References

Hester JP, et al. Stem Cell Collection. In: Apheresis: Principles and Practice. 3rd ed.

Examples

# Example 1: Standard Collection
# 70kg patient, CD34 count 20/uL, Target 5 million/kg, 50% efficiency
# Vol = (5 * 70) / (20 * 0.5) = 350 / 10 = 35 Liters
pbsc_collection_volume(70, 20, 5, 50)

# Example 2: High Efficiency, Low Count
# 80kg, CD34 10/uL, Target 2 million/kg, 40% efficiency
# Vol = (2 * 80) / (10 * 0.4) = 160 / 4 = 40 Liters
pbsc_collection_volume(80, 10, 2, 40)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.