rai_cll_staging: Rai Staging System for Chronic Lymphocytic Leukemia (CLL)

In cliot: Clinical Indices and Outcomes Tools

Rai Staging System for Chronic Lymphocytic Leukemia (CLL)

Description

Calculates the Rai Stage for patients with Chronic Lymphocytic Leukemia (CLL). This staging system stratifies patients into Low, Intermediate, and High risk groups based on the presence of lymphocytosis, lymphadenopathy, organomegaly (hepatomegaly or splenomegaly), anemia, and thrombocytopenia.

Usage

rai_cll_staging(lymphocytosis, lymphadenopathy, organomegaly,
                hemoglobin_lt_11, platelets_lt_100)

Arguments

lymphocytosis	Numeric (0 or 1). Presence of absolute lymphocytosis (>5,000/uL in blood and >=30% in marrow). (1 = Yes).
lymphadenopathy	Numeric (0 or 1). Presence of lymphadenopathy. (1 = Yes).
organomegaly	Numeric (0 or 1). Presence of hepatomegaly or splenomegaly. (1 = Yes).
hemoglobin_lt_11	Numeric (0 or 1). Hemoglobin < 11 g/dL (Anemia). (1 = Yes).
platelets_lt_100	Numeric (0 or 1). Platelets < 100,000/uL (Thrombocytopenia). (1 = Yes).

Value

A list containing:

Rai_Stage	The calculated stage (0, I, II, III, or IV).
Risk_Category	Risk stratification (Low, Intermediate, High).
Median_Survival	Historical median survival estimates based on the original 1975 cohort data.

References

Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-234.

Examples

# Example 1: High Risk (Stage IV)
# Lymphocytosis, Anemia, Thrombocytopenia
rai_cll_staging(1, 1, 1, 1, 1)

# Example 2: Low Risk (Stage 0)
# Lymphocytosis only
rai_cll_staging(1, 0, 0, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.