rebound_hyperbilirubinemia_score: Rebound Hyperbilirubinemia Risk Score

In cliot: Clinical Indices and Outcomes Tools

Rebound Hyperbilirubinemia Risk Score

Description

Calculates the risk of rebound hyperbilirubinemia (return of total serum bilirubin to phototherapy threshold within 72 hours) after discontinuation of inpatient phototherapy in neonates >= 35 weeks gestation. The score uses gestational age, age at phototherapy initiation, and the difference between the AAP phototherapy threshold and the TSB level at termination.

Usage

rebound_hyperbilirubinemia_score(gestational_age_weeks, age_initiation_hours,
                                 tsb_termination_mg_dl, aap_threshold_mg_dl)

Arguments

gestational_age_weeks	Numeric. Gestational age in weeks (Must be >= 35).
age_initiation_hours	Numeric. Postnatal age in hours at the time phototherapy was initiated.
tsb_termination_mg_dl	Numeric. Total Serum Bilirubin level (mg/dL) at the time of phototherapy discontinuation.
aap_threshold_mg_dl	Numeric. The AAP phototherapy treatment threshold (mg/dL) for the infant at the time of discontinuation.

Value

A list containing:

Rebound_Score	The calculated risk score.
Rebound_Risk_Probability	Estimated probability of rebound hyperbilirubinemia.

References

Chang PW, Kuzniewicz MW, McCulloch CE, Newman TB. A Clinical Prediction Rule for Rebound Hyperbilirubinemia Following Inpatient Phototherapy. Pediatrics. 2017;139(3):e20162896. doi:10.1542/peds.2016-2896

Examples

# Example 1: Low Risk
# 39 weeks, Started at 48 hours, TSB 12, Threshold 16 (Diff 4)
# Score = 0 - 7(2) - 4(4) + 50 = -14 - 16 + 50 = 20
rebound_hyperbilirubinemia_score(39, 48, 12, 16)

# Example 2: High Risk
# 36 weeks (<38), Started at 24 hours, TSB 13, Threshold 14 (Diff 1)
# Score = 15 - 7(1) - 4(1) + 50 = 15 - 7 - 4 + 50 = 54
rebound_hyperbilirubinemia_score(36, 24, 13, 14)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.