regiscar_dress_score: RegiSCAR Score for DRESS Syndrome

In cliot: Clinical Indices and Outcomes Tools

RegiSCAR Score for DRESS Syndrome

Description

Calculates the RegiSCAR score to diagnose Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). The score evaluates clinical features including fever, lymphadenopathy, hematologic abnormalities, skin involvement, organ involvement, and exclusion of other causes.

Usage

regiscar_dress_score(fever_gt_385, lymphadenopathy, eosinophil_count,
                     atypical_lymphocytes, skin_extent_gt_50,
                     skin_suggestive_features, organ_involvement_count,
                     other_causes_excluded, resolution_gt_15_days = 1)

Arguments

fever_gt_385	Numeric (0 or 1). Fever > 38.5 degrees Celsius. (1 = Yes, +1 point).
lymphadenopathy	Numeric (0 or 1). Enlarged lymph nodes in >= 2 sites (> 1 cm). (1 = Yes, +1 point).
eosinophil_count	Numeric. Absolute Eosinophil Count (cells/uL). (>= 700: +1, >= 1500: +2).
atypical_lymphocytes	Numeric (0 or 1). Presence of atypical lymphocytes. (1 = Yes, +1 point).
skin_extent_gt_50	Numeric (0 or 1). Skin rash extent > 50% body surface area. (1 = Yes, +1 point).
skin_suggestive_features	Numeric (0 or 1). Presence of at least 2 suggestive skin features (e.g., infiltration, purpura, scaling, facial edema). (1 = Yes, +1 point).
organ_involvement_count	Numeric. Number of internal organs involved (e.g., liver, kidney, lung). (1 organ: +1, >=2 organs: +2).
other_causes_excluded	Numeric (0 or 1). Were other potential causes (e.g., viral infections, ANA, blood culture) excluded? (1 = Yes, +1 point).
resolution_gt_15_days	Numeric (0 or 1). Did the reaction last more than 15 days? (1 = Yes, 0 pts; 0 = No, -1 point). Defaults to 1 (Yes) as DRESS is typically persistent.

Value

A list containing:

RegiSCAR_Score	The calculated total score.
Diagnosis	Diagnostic classification (No, Possible, Probable, or Definite DRESS).

References

Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol. 2007;156(3):609-611. doi:10.1111/j.1365-2133.2006.07704.x

Examples

# Example 1: Probable DRESS
# Fever(+1), Eos 900(+1), Atypical Lymphs(+1), Rash >50%(+1), No organs(0)
# Score = 4
regiscar_dress_score(1, 0, 900, 1, 1, 0, 0, 0, 1)

# Example 2: Definite DRESS
# Fever(+1), Nodes(+1), Eos 2000(+2), Rash Feat(+1), Liver/Kidney(+2)
# Score = 7
regiscar_dress_score(1, 1, 2000, 0, 0, 1, 2, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.