rema_mastocytosis_score: Spanish Network on Mastocytosis (REMA) Score

In cliot: Clinical Indices and Outcomes Tools

Spanish Network on Mastocytosis (REMA) Score

Description

Calculates the REMA Score to predict the presence of clonal mast cell disease (Systemic Mastocytosis or Monoclonal Mast Cell Activation Syndrome) in patients with mast cell activation symptoms but without skin lesions (systemic mastocytosis sine urticaria pigmentosa). A score of 2 or higher suggests a higher probability of clonality and may warrant bone marrow biopsy.

Usage

rema_mastocytosis_score(sex, clinical_symptoms, tryptase_level)

Arguments

sex	String. Patient sex ("male" or "female"). Male: +2 points. Female: -4 points.
clinical_symptoms	String. The primary clinical presentation. "pruritus_urticaria_angioedema": Pruritus, urticaria, or angioedema (-4 points). "syncope_presyncope": Syncope or presyncope (+3 points). "anaphylaxis": Anaphylaxis (+1 point). "other": Other symptoms (0 points).
tryptase_level	Numeric. Baseline serum tryptase level in ng/mL. < 15: 0 points. 15 - 24.9: +1 point. >= 25: +2 points.

Value

A list containing:

REMA_Score	The calculated total score (Range -8 to +7).
Prediction	Interpretation of probability (Low < 2, High >= 2).
Test_Characteristics_at_Cutoff_2	Sensitivity and Specificity metrics.

References

Alvarez-Twose I, González-de-Olano D, Sánchez-Muñoz L, et al. Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms. J Allergy Clin Immunol. 2010;125(6):1269-1278.e2. doi:10.1016/j.jaci.2010.02.019

Examples

# Example 1: High Probability
# Male (+2), Syncope (+3), Tryptase 20 (+1)
# Score = 6
rema_mastocytosis_score("male", "syncope_presyncope", 20)

# Example 2: Low Probability
# Female (-4), Urticaria (-4), Tryptase 10 (0)
# Score = -8
rema_mastocytosis_score("female", "pruritus_urticaria_angioedema", 10)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.