reticulocyte_indices: Absolute Reticulocyte Count & Reticulocyte Index

In cliot: Clinical Indices and Outcomes Tools

Absolute Reticulocyte Count & Reticulocyte Index

Description

Calculates hematological indices to assess bone marrow response to anemia. 1. **Absolute Reticulocyte Count (ARC):** Actual number of reticulocytes per volume of blood. 2. **Reticulocyte Index (RI):** Corrects the reticulocyte count for the degree of anemia (Hematocrit). 3. **Reticulocyte Production Index (RPI):** Further corrects the RI for the premature release of reticulocytes from the marrow (Maturation Shift), providing the most accurate assessment of effective RBC production.

Usage

reticulocyte_indices(retic_percent, rbc_count_million,
                     hematocrit_percent, normal_hct = 45)

Arguments

retic_percent	Numeric. The percentage of red blood cells that are reticulocytes (e.g., 2.5).
rbc_count_million	Numeric. The Red Blood Cell count in millions/uL (or 10^12/L). (e.g., 3.5).
hematocrit_percent	Numeric. The patient's Hematocrit percentage (e.g., 30).
normal_hct	Numeric. The expected normal Hematocrit. Defaults to 45%.

Value

A list containing:

Absolute_Reticulocyte_Count	Total reticulocytes (cells/uL).
Reticulocyte_Index	Corrected count based on hematocrit reduction.
Reticulocyte_Production_Index	The RI corrected for maturation time (shift correction).
Marrow_Response	Interpretation of the RPI (Adequate > 3, Inadequate < 2).

References

Hillman RS, Finch CA. Red Cell Manual. 7th ed. Philadelphia, Pa: FA Davis Co; 1996.

Examples

# Example 1: Hemolytic Anemia (Appropriate Response)
# Retic 15%, RBC 2.5 M/uL, Hct 25%
# ARC = 375,000; RI = 8.33; RPI = 8.33 / 2.0 = 4.16 (Adequate)
reticulocyte_indices(15, 2.5, 25)

# Example 2: Hypoproliferative Anemia (Inadequate Response)
# Retic 2%, RBC 3.0 M/uL, Hct 28%
# ARC = 60,000; RI = 1.24; RPI = 1.24 / 2.0 = 0.62 (Inadequate)
reticulocyte_indices(2, 3.0, 28)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.