rome_iv_reflux_hypersensitivity: Rome IV Diagnostic Criteria for Reflux Hypersensitivity

In cliot: Clinical Indices and Outcomes Tools

Rome IV Diagnostic Criteria for Reflux Hypersensitivity

Description

Evaluates the **Rome IV criteria** for diagnosing **Reflux Hypersensitivity**. This disorder is characterized by retrosternal symptoms (heartburn or chest pain) caused by physiological amounts of reflux (non-acid or acid) in patients who are refractory to proton pump inhibitor (PPI) therapy and lack endoscopic evidence of erosive esophagitis.

Usage

rome_iv_reflux_hypersensitivity(retrosternal_symptoms_bothersome, normal_egd,
                                 reflux_excluded, symptoms_refractory_to_ppis,
                                 symptoms_triggered_by_reflux,
                                 symptoms_not_associated_with_major_motility,
                                 symptom_onset_ge_6_months,
                                 symptoms_active_last_3_months)

Arguments

retrosternal_symptoms_bothersome	Numeric (0 or 1). Presence of bothersome retrosternal symptoms (heartburn or chest pain). (1 = Yes).
normal_egd	Numeric (0 or 1). Normal Esophagogastroduodenoscopy (EGD) (i.e., no erosive esophagitis). (1 = Yes).
reflux_excluded	Numeric (0 or 1). Absence of pathological reflux (negative symptom association probability or acid exposure time). (1 = Yes).
symptoms_refractory_to_ppis	Numeric (0 or 1). Refractory to optimized antisecretory therapy (e.g., maximal PPIs). (1 = Yes).
symptoms_triggered_by_reflux	Numeric (0 or 1). Symptoms are triggered by reflux events (positive symptom association probability or symptom index on reflux monitoring). (1 = Yes).
symptoms_not_associated_with_major_motility	Numeric (0 or 1). Absence of major esophageal motor disorders (e.g., achalasia, spasm). (1 = Yes).
symptom_onset_ge_6_months	Numeric (0 or 1). Did symptom onset occur at least **6 months ago**? (1 = Yes).
symptoms_active_last_3_months	Numeric (0 or 1). Have symptoms been active for the last **3 months**? (1 = Yes).

Value

A list containing:

Diagnosis

"Criteria Met for Reflux Hypersensitivity" or "Criteria Not Met".

References

Aben-Fawaz H, Kahrilas PJ, Chen J. Esophageal disorders. Gastroenterology. 2016;150:1367-1379. doi:10.1053/j.gastro.2016.02.002

Examples

# Example 1: Diagnosis Met
# All criteria met (bothersome symptoms, normal EGD, triggered by normal reflux,
#PPI refractory, no motility issues, chronic duration)
rome_iv_reflux_hypersensitivity(1, 1, 1, 1, 1, 1, 1, 1)

# Example 2: Not Met (Pathological Reflux Present)
# Reflux monitoring shows excessive acid exposure time (0 for reflux_excluded)
rome_iv_reflux_hypersensitivity(1, 1, 0, 1, 1, 1, 1, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.