safe_fibrosis_score: Steatosis-Associated Fibrosis Estimator (SAFE) Score

In cliot: Clinical Indices and Outcomes Tools

Steatosis-Associated Fibrosis Estimator (SAFE) Score

Description

Calculates the SAFE score to predict the presence of significant liver fibrosis (stage F2 or higher) in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) / Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The score uses age, BMI, diabetes status, platelet count, AST/ALT ratio, and serum globulin.

Usage

safe_fibrosis_score(age, bmi, diabetes, platelets, alt, ast, globulin)

Arguments

age	Numeric. Patient age in years.
bmi	Numeric. Body Mass Index in kg/m^2.
diabetes	Numeric (0 or 1). Presence of Type 2 Diabetes Mellitus. (1 = Yes).
platelets	Numeric. Platelet count in x10^9/L.
alt	Numeric. Alanine Aminotransferase level in U/L.
ast	Numeric. Aspartate Aminotransferase level in U/L.
globulin	Numeric. Serum Globulin level in g/dL. (Can be calculated as Total Protein - Albumin).

Details

The regression formula used is:

SAFE = -4.782 + (0.037 \times Age) + (0.094 \times BMI) + (1.13 \times Diabetes) + (0.99 \times \frac{AST}{ALT}) - (0.013 \times Platelets) + (0.66 \times Globulin)

A score > 0 indicates a high risk of significant fibrosis (>= F2).

Value

A list containing:

SAFE_Score	The calculated logit score.
Probability	The estimated probability of significant fibrosis.
Interpretation	Risk classification based on the 0 cutoff.

References

Alkhouri N, et al. The Steatosis-Associated Fibrosis Estimator (SAFE) Score: A Novel Score to Detect Significant Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease. 2018.

Examples

# Example 1: High Risk
# Age 50, BMI 35, Diabetes Yes, Plt 150, ALT 40, AST 50 (Ratio 1.25), Globulin 3.5
safe_fibrosis_score(50, 35, 1, 150, 40, 50, 3.5)

# Example 2: Low Risk
# Age 30, BMI 25, No Diabetes, Plt 250, ALT 30, AST 20 (Ratio 0.67), Globulin 2.5
safe_fibrosis_score(30, 25, 0, 250, 30, 20, 2.5)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.