sic_score: Sepsis-Induced Coagulopathy (SIC) Score

In cliot: Clinical Indices and Outcomes Tools

Sepsis-Induced Coagulopathy (SIC) Score

Description

Calculates the Sepsis-Induced Coagulopathy (SIC) score to identify patients with sepsis who are developing coagulopathy. This score serves as an early warning system for Disseminated Intravascular Coagulation (DIC) and is useful for selecting patients for anticoagulant therapy trials in sepsis.

Usage

sic_score(platelet_count, inr, sofa_total_score)

Arguments

platelet_count	Numeric. Platelet count in x10^9/L. < 100: +2 pts. 100-150: +1 pt. >= 150: 0 pts.
inr	Numeric. International Normalized Ratio. > 1.4: +2 pts. > 1.2 - 1.4: +1 pt. <= 1.2: 0 pts.
sofa_total_score	Numeric. The total Sequential Organ Failure Assessment (SOFA) score. >= 2: +2 pts. 1: +1 pt. 0: 0 pts.

Value

A list containing:

SIC_Score	The calculated score (Range 0-6).
Classification	"Sepsis-Induced Coagulopathy (SIC)" if Score >= 4, otherwise "No SIC".

References

Iba T, Nisio MD, Levy JH, et al. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a poster-hoc analysis of the FACS trial. Crit Care. 2017;21:209. doi:10.1186/s13054-017-1790-7

Examples

# Example 1: SIC Present
# Plt 80 (2), INR 1.5 (2), SOFA 5 (2)
# Score = 6
sic_score(80, 1.5, 5)

# Example 2: No SIC
# Plt 160 (0), INR 1.1 (0), SOFA 3 (2)
# Score = 2
sic_score(160, 1.1, 3)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.