simon_broome_fh_criteria: Simon Broome Diagnostic Criteria for Familial...

In cliot: Clinical Indices and Outcomes Tools

Simon Broome Diagnostic Criteria for Familial Hypercholesterolemia (FH)

Description

Evaluates the Simon Broome criteria to diagnose Familial Hypercholesterolemia (FH). The diagnosis is based on elevated cholesterol levels combined with physical signs (xanthomas), family history, or DNA evidence. A diagnosis can be "Definite FH" or "Possible FH".

Usage

simon_broome_fh_criteria(adult, total_cholesterol, ldl_cholesterol,
                         tendinous_xanthoma, fh_premature_chd,
                         fh_hypercholesterolemia, dna_mutation, units = "mg/dL")

Arguments

adult	Numeric (0 or 1). Is the patient an adult (age > 16)? (1 = Yes).
total_cholesterol	Numeric. Total cholesterol level.
ldl_cholesterol	Numeric. LDL cholesterol level.
tendinous_xanthoma	Numeric (0 or 1). Presence of tendinous xanthoma in the patient or a 1st/2nd degree relative. (1 = Yes).
fh_premature_chd	Numeric (0 or 1). Family history of myocardial infarction (MI) at age < 60 in 1st degree relative or < 50 in 2nd degree relative. (1 = Yes).
fh_hypercholesterolemia	Numeric (0 or 1). Family history of elevated cholesterol (> 7.5 mmol/L) in 1st/2nd degree relative. (1 = Yes).
dna_mutation	Numeric (0 or 1). Evidence of a functional mutation in LDLR, APOB, or PCSK9 gene. (1 = Yes).
units	String. Units for cholesterol input. Options: "mg/dL" (default) or "mmol/L".

Details

Cholesterol Thresholds: - Adult: Total Cholesterol > 7.5 mmol/L (290 mg/dL) or LDL > 4.9 mmol/L (190 mg/dL) - Child: Total Cholesterol > 6.7 mmol/L (260 mg/dL) or LDL > 4.0 mmol/L (155 mg/dL)

Diagnosis: - Definite FH: Cholesterol threshold met PLUS (Tendinous xanthoma OR DNA mutation). - Possible FH: Cholesterol threshold met PLUS (Family Hx of premature CHD OR Family Hx of hypercholesterolemia).

Value

A list containing:

Diagnosis	The diagnostic classification (Definite FH, Possible FH, or Unlikely FH).
Cholesterol_Met	Boolean indicating if the cholesterol threshold was met.

References

Scientific Steering Committee on behalf of the Simon Broome Register Group. Risk of fatal coronary heart disease in familial hypercholesterolaemia. BMJ. 1991;303(6807):893-896.

Examples

# Example 1: Definite FH (Adult)
# LDL 200 mg/dL (>190), Xanthoma present
simon_broome_fh_criteria(1, 300, 200, 1, 0, 0, 0)

# Example 2: Possible FH (Child)
# LDL 160 mg/dL (>155), Family Hx of high chol
simon_broome_fh_criteria(0, 270, 160, 0, 0, 1, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.