simplified_aih_score: Simplified Autoimmune Hepatitis (AIH) Score

In cliot: Clinical Indices and Outcomes Tools

Simplified Autoimmune Hepatitis (AIH) Score

Description

Calculates the Simplified AIH Score (2008) to aid in the diagnosis of Autoimmune Hepatitis. The score is based on four parameters: autoantibodies, IgG levels, liver histology, and the absence of viral hepatitis.

Usage

simplified_aih_score(ana_or_sma_titer, lkm_titer, sla_antibody_positive,
                     igg_level, igg_uln, liver_histology, viral_hepatitis_absent)

Arguments

ana_or_sma_titer	String. Titer of ANA or SMA antibodies. Options: "none", ">=1:40", ">=1:80".
lkm_titer	String. Titer of LKM antibodies. Options: "none", ">=1:40".
sla_antibody_positive	Numeric (0 or 1). Presence of Soluble Liver Antigen (SLA) antibodies. (1 = Positive).
igg_level	Numeric. Patient's serum IgG level.
igg_uln	Numeric. Upper Limit of Normal for IgG level in the lab.
liver_histology	String. Histological findings. Options: "typical" (interface hepatitis, emperipolesis, rosettes), "compatible" (chronic hepatitis without all typical features), "atypical" (signs of another diagnosis).
viral_hepatitis_absent	Numeric (0 or 1). Absence of viral hepatitis markers (A, B, C). (1 = Yes, markers absent).

Value

A list containing:

Simplified_AIH_Score	The calculated total score (Range 0-8).
Diagnosis	Interpretation (Probable AIH >= 6, Definite AIH >= 7).

References

Hennes EM, Zeniya M, Czaja AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008;48(1):169-176. doi:10.1002/hep.22322

Examples

# Example 1: Definite AIH
# ANA >=1:80 (2), IgG >1.1x ULN (2), Typical Histology (2), No Viral Hep (2)
# Score = 8
simplified_aih_score(">=1:80", "none", 0, 1800, 1500, "typical", 1)

# Example 2: Probable AIH
# ANA >=1:40 (1), IgG Normal (0), Compatible Histology (1), No Viral Hep (2)
# Score = 4 (Not Diagnostic - Wait, calculation: 1+0+1+2 = 4. Correct.)
simplified_aih_score(">=1:40", "none", 0, 1000, 1500, "compatible", 1)

# Example 3: Probable AIH (Score 6)
# ANA >=1:40 (1), IgG >1.1x (2), Compatible (1), No Viral (2) -> 6
simplified_aih_score(">=1:40", "none", 0, 1800, 1500, "compatible", 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.