sledai_2k_score: Systemic Lupus Erythematosus Disease Activity Index 2000...

In cliot: Clinical Indices and Outcomes Tools

Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K)

Description

Calculates the SLEDAI-2K score to assess global disease activity in patients with Systemic Lupus Erythematosus (SLE). It assesses the presence of 24 specific clinical and laboratory variables over the last 10 days (or since the last visit).

Usage

sledai_2k_score(seizure, psychosis, organic_brain_syndrome, visual_disturbance,
                cranial_nerve_disorder, lupus_headache, cva, vasculitis,
                arthritis, myositis, urinary_casts, hematuria, proteinuria,
                pyuria, rash, alopecia, mucosal_ulcers, pleurisy, pericarditis,
                low_complement, increased_dna_binding, fever, thrombocytopenia,
                leukopenia)

Arguments

seizure	Numeric (0 or 1). Recent onset of seizure. (1 = Yes, 8 points).
psychosis	Numeric (0 or 1). Altered ability to function in normal activity due to severe disturbance in the perception of reality. (1 = Yes, 8 points).
organic_brain_syndrome	Numeric (0 or 1). Altered mental function with impaired orientation, memory, or other intellectual function. (1 = Yes, 8 points).
visual_disturbance	Numeric (0 or 1). Retinal changes of SLE. (1 = Yes, 8 points).
cranial_nerve_disorder	Numeric (0 or 1). New onset of sensory or motor neuropathy involving cranial nerves. (1 = Yes, 8 points).
lupus_headache	Numeric (0 or 1). Severe, persistent headache. (1 = Yes, 8 points).
cva	Numeric (0 or 1). New onset of cerebrovascular accident (CVA). (1 = Yes, 8 points).
vasculitis	Numeric (0 or 1). Ulceration, gangrene, tender finger nodules, periungual infarction, splinter hemorrhages, or biopsy/angiogram proof. (1 = Yes, 8 points).
arthritis	Numeric (0 or 1). More than 2 joints with pain and signs of inflammation (i.e., tenderness, swelling, or effusion). (1 = Yes, 4 points).
myositis	Numeric (0 or 1). Proximal muscle aching/weakness, associated with elevated CPK/aldolase or EMG changes or biopsy. (1 = Yes, 4 points).
urinary_casts	Numeric (0 or 1). Heme-granular or red blood cell casts. (1 = Yes, 4 points).
hematuria	Numeric (0 or 1). >5 red blood cells/high power field. (1 = Yes, 4 points).
proteinuria	Numeric (0 or 1). >0.5g/24 hours. (1 = Yes, 4 points).
pyuria	Numeric (0 or 1). >5 white blood cells/high power field. (1 = Yes, 4 points).
rash	Numeric (0 or 1). Inflammatory type rash. (1 = Yes, 2 points).
alopecia	Numeric (0 or 1). Abnormal, patchy or diffuse loss of hair. (1 = Yes, 2 points).
mucosal_ulcers	Numeric (0 or 1). Oral or nasal ulceration. (1 = Yes, 2 points).
pleurisy	Numeric (0 or 1). Pleuritic chest pain with pleural rub or effusion or pleural thickening. (1 = Yes, 2 points).
pericarditis	Numeric (0 or 1). Pericardial pain with rub or effusion or EKG confirmation. (1 = Yes, 2 points).
low_complement	Numeric (0 or 1). Decrease in CH50, C3, or C4 below the lower limit of normal. (1 = Yes, 2 points).
increased_dna_binding	Numeric (0 or 1). Increased DNA binding by Farr assay (above normal). (1 = Yes, 2 points).
fever	Numeric (0 or 1). >38 degrees C. (1 = Yes, 1 point).
thrombocytopenia	Numeric (0 or 1). <100,000 platelets/mm^3. (1 = Yes, 1 point).
leukopenia	Numeric (0 or 1). <3,000 white blood cells/mm^3. (1 = Yes, 1 point).

Value

A list containing:

SLEDAI_2K_Score	The calculated total score.
Disease_Activity	Interpretation of the score (No Activity, Mild, Moderate, High, Very High).

References

Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29(2):288-291.

Examples

# Example 1: Moderate Activity
# Arthritis (4), Rash (2), Fever (1)
# Score = 7
sledai_2k_score(0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0)

# Example 2: High Activity
# Vasculitis (8), Low Complement (2), Increased DNA Binding (2)
# Score = 12
sledai_2k_score(0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.