slicc_sle_criteria: SLICC Criteria for Systemic Lupus Erythematosus (SLE)

In cliot: Clinical Indices and Outcomes Tools

SLICC Criteria for Systemic Lupus Erythematosus (SLE)

Description

Evaluates the 2012 SLICC (Systemic Lupus International Collaborating Clinics) criteria for the diagnosis of Systemic Lupus Erythematosus. Diagnosis requires either: 1) Biopsy-proven lupus nephritis with positive ANA or Anti-dsDNA, OR 2) At least 4 criteria met, including at least one clinical criterion and one immunologic criterion.

Usage

slicc_sle_criteria(acute_cutaneous_lupus, chronic_cutaneous_lupus, oral_ulcers,
                   alopecia, synovitis, serositis, renal_clinical, neurologic,
                   hemolytic_anemia, leukopenia_lymphopenia, thrombocytopenia,
                   ana, anti_dsdna, anti_sm, antiphospholipid_antibody,
                   low_complement, direct_coombs, biopsy_proven_nephritis)

Arguments

acute_cutaneous_lupus	Numeric (0/1). Presence of acute cutaneous lupus (e.g., malar rash).
chronic_cutaneous_lupus	Numeric (0/1). Presence of chronic cutaneous lupus (e.g., discoid rash).
oral_ulcers	Numeric (0/1). Oral or nasal ulcers.
alopecia	Numeric (0/1). Non-scarring alopecia.
synovitis	Numeric (0/1). Synovitis involving 2 or more joints.
serositis	Numeric (0/1). Serositis (pleuritis or pericarditis).
renal_clinical	Numeric (0/1). Renal criteria (urine protein/creatinine ratio or red blood cell casts).
neurologic	Numeric (0/1). Neurologic criteria (seizures, psychosis, etc.).
hemolytic_anemia	Numeric (0/1). Hemolytic anemia.
leukopenia_lymphopenia	Numeric (0/1). Leukopenia (<4000/mm3) or Lymphopenia (<1000/mm3).
thrombocytopenia	Numeric (0/1). Thrombocytopenia (<100,000/mm3).
ana	Numeric (0/1). Positive ANA (Antinuclear Antibody).
anti_dsdna	Numeric (0/1). Positive Anti-dsDNA.
anti_sm	Numeric (0/1). Positive Anti-Sm.
antiphospholipid_antibody	Numeric (0/1). Positive Antiphospholipid antibody.
low_complement	Numeric (0/1). Low complement (C3, C4, or CH50).
direct_coombs	Numeric (0/1). Positive Direct Coombs test. (Note: Counts as immunologic criterion only in the absence of hemolytic anemia).
biopsy_proven_nephritis	Numeric (0/1). Biopsy-proven lupus nephritis.

Value

A list containing:

Diagnosis	"Systemic Lupus Erythematosus (SLE)" or "Criteria Not Met".
Total_Criteria_Met	Count of total criteria met (adjusted for Coombs rule).
Breakdown	Breakdown of Clinical and Immunologic counts.

References

Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-2686. doi:10.1002/art.34473

Examples

# Example 1: Diagnosis via Criteria Count
# Malar rash (1), Arthritis (1), Renal (1), ANA (1) -> 3 Clinical, 1 Immuno, Total 4
slicc_sle_criteria(1, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0)

# Example 2: Diagnosis via Biopsy
# No clinical symptoms, but Biopsy Nephritis (1) and ANA (1)
slicc_sle_criteria(0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.