ssign_rcc_score: SSIGN Score for Renal Cell Carcinoma (RCC)

In cliot: Clinical Indices and Outcomes Tools

SSIGN Score for Renal Cell Carcinoma (RCC)

Description

Calculates the SSIGN (Stage, Size, Grade, and Necrosis) Score to predict cancer-specific survival outcomes in patients with clear cell Renal Cell Carcinoma (ccRCC) after radical or partial nephrectomy.

Usage

ssign_rcc_score(pathologic_t_stage, lymph_node_status, metastasis_status,
                tumor_size_ge_5cm, fuhrman_grade, tumor_necrosis_present)

Arguments

pathologic_t_stage	String. Pathologic T Stage (2002 TNM). "t1a": 0 pts. "t1b": 2 pts. "t2": 3 pts. "t3a", "t3b", "t3c": 4 pts. "t4": 5 pts.
lymph_node_status	String. Regional Lymph Node status. "n0" or "nx": 0 pts. "n1" or "n2": 2 pts.
metastasis_status	Numeric (0 or 1). Distant metastasis (M1). (1 = Yes, +4 pts).
tumor_size_ge_5cm	Numeric (0 or 1). Tumor size >= 5 cm. (1 = Yes, +2 pts).
fuhrman_grade	Numeric (1-4). Fuhrman Nuclear Grade. 1 or 2: 0 pts. 3: 1 pt. 4: 3 pts.
tumor_necrosis_present	Numeric (0 or 1). Presence of tumor necrosis. (1 = Yes, +2 pts).

Value

A list containing:

SSIGN_Score	The calculated total score (Range 0-18).
Est_5_Year_Survival	Estimated 5-year cancer-specific survival percentage.

References

Frank I, Blute ML, Cheville JC, et al. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol. 2002;168(6):2395-2400. doi:10.1016/S0022-5347(05)64153-5

Examples

# Example 1: High Risk
# T3a (+4), N0 (0), M0 (0), Size 6cm (+2), Grade 4 (+3), Necrosis (+2)
# Score = 11
ssign_rcc_score("t3a", "n0", 0, 1, 4, 1)

# Example 2: Low Risk
# T1a (0), N0 (0), M0 (0), Size 3cm (0), Grade 2 (0), No Necrosis (0)
# Score = 0
ssign_rcc_score("t1a", "n0", 0, 0, 2, 0)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.