tenecteplase_dosing: Tenecteplase (TNKase) Dosing Calculator

In cliot: Clinical Indices and Outcomes Tools

Tenecteplase (TNKase) Dosing Calculator

Description

Calculates the recommended dose of Tenecteplase for the treatment of Acute Myocardial Infarction (STEMI) or Acute Ischemic Stroke. Dosing for STEMI is based on weight tiers, while dosing for stroke is calculated as 0.25 mg/kg with a maximum limit.

Usage

tenecteplase_dosing(weight_kg, indication = "stemi")

Arguments

weight_kg	Numeric. Patient weight in kilograms.
indication	String. Clinical indication for treatment. Options: "stemi" (default) or "stroke". STEMI Dosing: <60 kg: 30 mg 60-69 kg: 35 mg 70-79 kg: 40 mg 80-89 kg: 45 mg >=90 kg: 50 mg Stroke Dosing: 0.25 mg/kg (Max 25 mg).

Value

A list containing:

Recommended_Dose_mg	The calculated dose in milligrams.
Volume_to_Administer_mL	The volume to administer in milliliters (based on standard 5 mg/mL reconstitution).

References

TNKase (Tenecteplase) [Package Insert]. South San Francisco, CA: Genentech, Inc. Haley EC Jr, et al. Tenecteplase in acute ischemic stroke: results of a randomized controlled trial. Stroke. 2010;41(4):707-711.

Examples

# Example 1: STEMI, 75 kg
# Tier 70-79kg -> 40 mg
tenecteplase_dosing(75, "stemi")

# Example 2: Stroke, 110 kg
# 0.25 * 110 = 27.5 mg -> Capped at 25 mg
tenecteplase_dosing(110, "stroke")

cliot documentation built on Dec. 1, 2025, 1:06 a.m.