us_medped_fh_criteria: US MEDPED Diagnostic Criteria for Familial...

In cliot: Clinical Indices and Outcomes Tools

US MEDPED Diagnostic Criteria for Familial Hypercholesterolemia (FH)

Description

Calculates the US MEDPED (Make Early Diagnosis to Prevent Early Deaths) diagnostic criteria for Familial Hypercholesterolemia. The diagnosis is based on age-specific total cholesterol thresholds and the degree of relationship to a known relative with FH.

Usage

us_medped_fh_criteria(age, total_cholesterol, relative_with_fh, units = "mg/dL")

Arguments

age	Numeric. Patient age in years.
total_cholesterol	Numeric. Total cholesterol level.
relative_with_fh	String. The degree of relationship to a relative diagnosed with FH. Options: "first_degree" (Parent, Sibling, Child). "second_degree" (Grandparent, Aunt/Uncle, Niece/Nephew, Half-sibling). "third_degree" (First Cousin). "general_population" (No known relative with FH).
units	String. Units for cholesterol input. Options: "mg/dL" (default) or "mmol/L".

Details

Thresholds (mg/dL) for diagnosis: First Degree: <20y (220), 20-29y (240), 30-39y (270), >=40y (290). Second Degree: <20y (230), 20-29y (250), 30-39y (280), >=40y (300). Third Degree: <20y (240), 20-29y (260), 30-39y (290), >=40y (310). General Population: <20y (270), 20-29y (290), 30-39y (340), >=40y (360).

Value

A list containing:

Diagnosis	"Diagnosed with Familial Hypercholesterolemia (FH)" or "Does Not Meet Criteria for FH".
Threshold_Used_mg_dL	The specific cholesterol cutoff used for the assessment.

References

Williams RR, Hunt SC, Schumacher MC, et al. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol. 1993;72(2):171-176. doi:10.1016/0002-9149(93)90155-6

Examples

# Example 1: FH Diagnosed
# 35yo, Cholesterol 300 mg/dL, First-degree relative with FH
us_medped_fh_criteria(35, 300, "first_degree")

# Example 2: Not FH
# 50yo, Cholesterol 250 mg/dL, General Population
us_medped_fh_criteria(50, 250, "general_population")

cliot documentation built on Dec. 1, 2025, 1:06 a.m.