who_pv_criteria: WHO Diagnostic Criteria for Polycythemia Vera (2016)

In cliot: Clinical Indices and Outcomes Tools

WHO Diagnostic Criteria for Polycythemia Vera (2016)

Description

Evaluates the 2016 World Health Organization (WHO) diagnostic criteria for Polycythemia Vera (PV). Diagnosis requires either all three major criteria, or the first two major criteria plus the minor criterion. NOTE: Bone marrow biopsy (Major Criterion 2) may not be required in cases with sustained absolute erythrocytosis (Hb >18.5 g/dL in men or >16.5 g/dL in women) if Major Criterion 3 and the Minor Criterion are present.

Usage

who_pv_criteria(sex, hemoglobin, hematocrit, red_cell_mass_elevated,
                bone_marrow_biopsy, jak2_mutation, serum_epo_low)

Arguments

sex	String. Patient sex ("Male" or "Female"). Used to determine hemoglobin/hematocrit thresholds.
hemoglobin	Numeric. Hemoglobin level in g/dL.
hematocrit	Numeric. Hematocrit percentage (0-100).
red_cell_mass_elevated	Numeric (0 or 1). Is the red cell mass > 25% above the mean normal predicted value? (1 = Yes). Alternative for Major Criterion 1.
bone_marrow_biopsy	Numeric (0 or 1). Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis). (1 = Yes). (Major Criterion 2).
jak2_mutation	Numeric (0 or 1). Presence of JAK2 V617F or JAK2 Exon 12 mutation. (1 = Yes). (Major Criterion 3).
serum_epo_low	Numeric (0 or 1). Subnormal serum erythropoietin level. (1 = Yes). (Minor Criterion).

Value

A list containing:

Diagnosis	"Criteria Met for Polycythemia Vera" or "Criteria Not Met".
Criteria_Status	A list of boolean values indicating which specific criteria were satisfied.

References

Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. doi:10.1182/blood-2016-03-643544

Examples

# Example 1: Diagnosis Met (3 Major Criteria)
# Male, Hb 17.0, Hct 50, Biopsy+, JAK2+
who_pv_criteria("male", 17.0, 50, 0, 1, 1, 0)

# Example 2: Diagnosis Met (2 Major + 1 Minor)
# Female, Hb 16.2, Hct 49, Biopsy+, JAK2-, Low EPO
who_pv_criteria("female", 16.2, 49, 0, 1, 0, 1)

cliot documentation built on Dec. 1, 2025, 1:06 a.m.