AED.boundary: Calculate the critical value used at the final analysis in...

In esDesign: Adaptive Enrichment Designs with Sample Size Re-Estimation

Description

AED.boundary() is used to calculate the critical value used at the final analysis in AED design, meanwhile preserving the overall type I error rate at α level

Usage

AED.boundary(rho, alpha, Info, epsilon)

Arguments

rho	The proportion of subgroup 1
alpha	The overall type I error rate
Info	The infromation fraction
epsilon	The threshold of difference between the subgroup-specific test statistics

Value

The critical value used at the final analysis

References

• Lin, R., Yang, Z., Yuan, Y. and Yin, G., 2021. Sample size re-estimation in adaptive enrichment design. Contemporary Clinical Trials, 100, p.106216. <doi: 10.1016/j.cct.2020.106216>

Examples

AED.boundary(rho = 0.5, alpha = 0.05, Info = 0.5, epsilon = 0.5)

esDesign documentation built on July 13, 2021, 9:06 a.m.