AED3_SSR.boundary: Calculate the futility and efficacy stopping boundaries in...

In esDesign: Adaptive Enrichment Designs with Sample Size Re-Estimation

Description

The AED3_SSR.boundary() is used to calculate the futility and efficacy stopping boundaries in the Adaptive Enrichment Design with Sample Size Re-estimation Procedure.

Usage

AED3_SSR.boundary(rho, alpha, pstar)

Arguments

rho	The proportion of subgroup 1
alpha	The overall Type I error rate
pstar	The (1 - power) of accepting the null hypothesis at the interim analysis.

Value

A list contains

• upper.boundary The upper or the efficacy stopping boundary

• lower.boundary The lower or the futility stopping boundary

Examples

rho <- 0.5
alpha <- 0.05
pstar <- 0.15
res <- AED3_SSR.boundary(rho = rho, alpha = alpha, pstar = pstar)

Example output

Futility/Efficacy stopping boundaries for AED3-SSR:

The futility stopping boundary =  1.036 .
The efficacy stopping boundary =  2.212 .

esDesign documentation built on July 13, 2021, 9:06 a.m.