Description Usage Arguments Value Examples

The `AED3_SSR.boundary()`

is used to calculate the futility
and efficacy stopping boundaries in the Adaptive Enrichment Design with
Sample Size Re-estimation Procedure.

1 | ```
AED3_SSR.boundary(rho, alpha, pstar)
``` |

`rho` |
The proportion of subgroup 1 |

`alpha` |
The overall Type I error rate |

`pstar` |
The |

A list contains

upper.boundary The upper or the efficacy stopping boundary

lower.boundary The lower or the futility stopping boundary

1 2 3 4 | ```
rho <- 0.5
alpha <- 0.05
pstar <- 0.15
res <- AED3_SSR.boundary(rho = rho, alpha = alpha, pstar = pstar)
``` |

```
Futility/Efficacy stopping boundaries for AED3-SSR:
The futility stopping boundary = 1.036 .
The efficacy stopping boundary = 2.212 .
```

esDesign documentation built on July 13, 2021, 9:06 a.m.

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