Description Usage Arguments References Examples

The `AED1_SSR.boundary()`

is used to calculate the critical
value required at the final analysis of the Adaptive Enrichment Design
(Strategy 1) with sample size
re-estimation procedure. In the AED1-SSR design, the adaptive enrichment
strategy is guided by a pre-specified futility stopping boundary and a
threshold of the difference between the subgroup-specific test statistics.

1 | ```
AED1_SSR.boundary(rho, alpha, pstar, Info, epsilon)
``` |

`rho` |
The proportion of subgroup 1. |

`alpha` |
The overall Type I error rate. |

`pstar` |
The |

`Info` |
The observation information, which is commonly calculated through the sample size used at each stage of the trial. |

`epsilon` |
The threshold of the difference between subgroup-specific test statistics. |

Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan. (2018) Sample Size Re-estimation in Adaptive Enrichment Trials. (In preparation)

1 | ```
AED1_SSR.boundary(rho = 0.5, alpha = 0.05, pstar = 0.2, Info = 0.5, epsilon = 0.5)
``` |

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