AED1_SSR.N2: Calculate the sample size required at the second stage of the...

In esDesign: Adaptive Enrichment Designs with Sample Size Re-Estimation

Description

The AED1_SSR.N2() is used to calculated the sample size required at the second stage of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure.

Usage

AED1_SSR.N2(c, z1, N1, beta)

Arguments

c	The critical value used at the final analysis
z1	The test statistic obtained at the interim analysis
N1	The sample size used at the first stage
beta	The (1 - power)

Value

The Value of the re-estimated sample size

References

• Lin, R., Yang, Z., Yuan, Y. and Yin, G., 2021. Sample size re-estimation in adaptive enrichment design. Contemporary Clinical Trials, 100, p.106216. <doi: 10.1016/j.cct.2020.106216>

Examples

c <- 2.258
z1 <- 1.974
N1 <- 248
beta <- 0.2
AED1_SSR.N2(c = c, z1 = z1, N1 = N1, beta = beta)

esDesign documentation built on July 13, 2021, 9:06 a.m.