Description Usage Arguments Value References Examples
The SSR.sim()
is used to implement the simulation studies
based on the Sample Size Re-estimation Procedure.
1 |
N |
The sample size used at the first stage. Note that this |
rho |
The proportion of subgroup 1 |
alpha |
The overall Type I error rate |
beta |
The |
theta |
The sizes of treatment effects for subgroups 1 and 2 in the experimental arm |
theta0 |
The size of treatment effect in the control arm |
sigma0 |
The variance of the treatment effect |
pstar |
The |
nSim |
The number of simulated studies |
Seed |
The random seed |
A list contains
nTotal The average total sample size used in SSR
H0 The power of SSR under the specific trial design. Here, the power is defined as the probability of rejecting the null hypothesis
ESF The percentage of early stopping for futility
ESE The percentage of early stopping for efficacy
Proschan MA, Hunsberger SA. Designed extension of studies based on conditional power. Biometrics 1995:1315-1324. <doi:10.2307/2533262>
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