Nothing
httk: High-Throughput Toxicokinetics
Generic models and chemical-specific data for simulation and statistical analysis of chemical toxicokinetics ("TK") as described by Pearce et al. (2017) <doi:10.18637/jss.v079.i04>. Chemical-specific in vitro data have been obtained from relatively high-throughput experiments. Both physiologically-based ("PBTK") and empirical (for example, one compartment) "TK" models can be parameterized with the data provided for thousands of chemicals, multiple exposure routes, and various species. The models consist of systems of ordinary differential equations which are solved using compiled (C-based) code for speed. A Monte Carlo sampler is included, which allows for simulating human biological variability (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>) and propagating parameter uncertainty. Calibrated methods are included for predicting tissue:plasma partition coefficients and volume of distribution (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>). These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high-throughput screening data (for example, Tox21, ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK") (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).
Getting started
Package overview
Frank et al. (2018): Creating IVIVE Figure (Fig. 6)"
Honda et al. (2019): Updated Armitage et al. (2014) Model"
Kapraun et al. (submitted): Generic Human Gestational Model"
Linakis et al. (2020): Analysis and Figure Generation"
Ring et al. (2017) Vignette 1: Generating subpopulations"
Ring et al. (2017) Vignette 6: AER plotting"
Wambaugh et al. (2018): Creating All Figures"
Browse package contents
Package details |
|
|---|---|
| Author | John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>), Sarah Davidson [aut] (<https://orcid.org/0000-0002-2891-9380>), Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>), Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>), Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>), Mark Sfeir [aut], Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>), Dustin Kapraun [aut] (<https://orcid.org/0000-0001-5570-6383>), Miyuki Breen [ctb] (<https://orcid.org/0000-0001-8511-4653>), Shannon Bell [ctb] (<https://orcid.org/0000-0002-5754-6085>), Xiaoqing Chang [ctb] (<https://orcid.org/0000-0003-0752-1848>), Todor Antonijevic [ctb] (<https://orcid.org/0000-0002-0248-8412>), Jimena Davis [ctb], James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>), Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>), Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>), Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>) |
| Maintainer | John Wambaugh <wambaugh.john@epa.gov> |
| License | GPL-3 |
| Version | 2.1.0 |
| URL | https://www.epa.gov/chemical-research/rapid-chemical-exposure-and-dose-research |
| Package repository | View on CRAN |
| Installation |
Install the latest version of this package by entering the following in R:
|
Try the httk package in your browser
Any scripts or data that you put into this service are public.
