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httk: High-Throughput Toxicokinetics
Version 1.7
Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").
Getting started
Package overview
AER plotting"
Age distributions"
Creating Figures in Partition Coefficient Evaluation"
Global sensitivity analysis"
Global sensitivity analysis plotting"
Height and weight spline fits and residuals"
Hematocrit spline fits and residuals"
Plotting Css95"
Plotting Howgate/Johnson data"
Serum creatinine spline fits and residuals"
Vignette 1: Generating subpopulations"
Vignette 2: Evaluating HTTK models for subpopulations"
Vignette 3: Generating Figure 2"
Vignette 4: Generating Figure 3"
Virtual study populations"
Browse package contents
Package details |
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| Author | John Wambaugh, Robert Pearce, Caroline Ring, Jimena Davis, Nisha Sipes, and R. Woodrow Setzer |
| Date of publication | 2017-07-15 06:28:45 UTC |
| Maintainer | John Wambaugh <wambaugh.john@epa.gov> |
| License | GPL-3 |
| Version | 1.7 |
| Package repository | View on CRAN |
| Installation |
Install the latest version of this package by entering the following in R:
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