available_rblood2plasma: Find the best available ratio of the blood to plasma...

In httk: High-Throughput Toxicokinetics

Find the best available ratio of the blood to plasma concentration constant.

Description

This function finds the best available constant ratio of the blood concentration to the plasma concentration, using get_rblood2plasma and calc_rblood2plasma.

Usage

available_rblood2plasma(
  chem.cas = NULL,
  chem.name = NULL,
  dtxsid = NULL,
  species = "Human",
  adjusted.Funbound.plasma = TRUE,
  class.exclude = TRUE,
  suppress.messages = FALSE
)

Arguments

chem.cas	Either the CAS number or the chemical name must be specified.
chem.name	Either the chemical name or the CAS number must be specified.
dtxsid	EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs
species	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
adjusted.Funbound.plasma	Whether or not to use Funbound.plasma adjustment if calculating Rblood2plasma.
class.exclude	Exclude chemical classes identified as outside of domain of applicability by relevant modelinfo_[MODEL] file (default TRUE).
suppress.messages	Whether or not to display relevant warning messages to user.

Details

Either retrieves a measured blood:plasma concentration ratio from the chem.physical_and_invitro.data table or calculates it using the red blood cell partition coefficient predicted with Schmitt's method

If available, in vivo data (from chem.physical_and_invitro.data) for the given species is returned, substituting the human in vivo value when missing for other species. In the absence of in vivo data, the value is calculated with calc_rblood2plasma for the given species. If Funbound.plasma is unvailable for the given species, the human Funbound.plasma is substituted. If none of these are available, the mean human Rblood2plasma from chem.physical_and_invitro.data is returned. details than the description above ~~

Value

The blood to plasma chemical concentration ratio – measured if available, calculated if not.

Author(s)

Robert Pearce

See Also

calc_rblood2plasma

get_rblood2plasma

Examples

available_rblood2plasma(chem.name="Bisphenol A",adjusted.Funbound.plasma=FALSE)
available_rblood2plasma(chem.name="Bisphenol A",species="Rat")

httk documentation built on Sept. 11, 2024, 9:32 p.m.