calc_total_clearance: Calculate the total plasma clearance.

In httk: High-Throughput Toxicokinetics

Calculate the total plasma clearance.

Description

This function calculates the total clearance rate for a one compartment model for plasma where clearance is entirely due to metablism by the liver and glomerular filtration in the kidneys, identical to clearance of three compartment steady state model.

Usage

calc_total_clearance(
  chem.cas = NULL,
  chem.name = NULL,
  dtxsid = NULL,
  parameters = NULL,
  model = "3compartmentss",
  species = "Human",
  suppress.messages = FALSE,
  default.to.human = FALSE,
  class.exclude = TRUE,
  restrictive.clearance = TRUE,
  ...
)

Arguments

chem.cas	Either the chemical name, CAS number, or the parameters must be specified.
chem.name	Either the chemical name, CAS number, or the parameters must be specified.
dtxsid	EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs
parameters	Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.
model	The model used to calculate total clearance (defaults to "3compartmentss")
species	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
suppress.messages	Whether or not the output message is suppressed.
default.to.human	Substitutes missing animal values with human values if true.
class.exclude	Exclude chemical classes identified as outside of domain of applicability by relevant modelinfo_[MODEL] file (default TRUE).
restrictive.clearance	Protein binding is not taken into account (set to 1) in liver clearance if FALSE.
...	Additional parameters passed to parameterize_steadystate if parameters is NULL.

Value

Total Clearance

Units of L/h/kg BW.

Author(s)

John Wambaugh

Examples

calc_total_clearance(chem.name="Ibuprofen") 

httk documentation built on April 3, 2025, 7:08 p.m.