calc_analytic_css_3compss: Calculate the analytic steady state concentration for the...
In httk: High-Throughput Toxicokinetics

View source: R/calc_analytic_css_3compss.R

calc_analytic_css_3compss

R Documentation

Calculate the analytic steady state concentration for the three compartment steady-state model

Description

This function calculates the analytic steady state plasma or venous blood concentrations as a result of infusion dosing.

Usage

calc_analytic_css_3compss(
  chem.name = NULL,
  chem.cas = NULL,
  dtxsid = NULL,
  parameters = NULL,
  hourly.dose = 1/24,
  concentration = "plasma",
  suppress.messages = FALSE,
  recalc.blood2plasma = FALSE,
  tissue = NULL,
  restrictive.clearance = TRUE,
  bioactive.free.invivo = FALSE,
  ...
)

Arguments

`chem.name`	Either the chemical name, CAS number, or the parameters must be specified.
`chem.cas`	Either the chemical name, CAS number, or the parameters must be specified.
`dtxsid`	EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs
`parameters`	Chemical parameters from parameterize_pbtk (for model = 'pbtk'), parameterize_3comp (for model = '3compartment), parameterize_1comp(for model = '1compartment') or parameterize_steadystate (for model = '3compartmentss'), overrides chem.name and chem.cas.
`hourly.dose`	Hourly dose rate mg/kg BW/h.
`concentration`	Desired concentration type, 'blood' or default 'plasma'.
`suppress.messages`	Whether or not the output message is suppressed.
`recalc.blood2plasma`	Recalculates the ratio of the amount of chemical in the blood to plasma using the input parameters. Use this if you have 'altered hematocrit, Funbound.plasma, or Krbc2pu.
`tissue`	Desired tissue concentration (defaults to whole body concentration.)
`restrictive.clearance`	If TRUE (default), then only the fraction of chemical not bound to protein is available for metabolism in the liver. If FALSE, then all chemical in the liver is metabolized (faster metabolism due to rapid off-binding).
`bioactive.free.invivo`	If FALSE (default), then the total concentration is treated as bioactive in vivo. If TRUE, the the unbound (free) plasma concentration is treated as bioactive in vivo. Only works with tissue = NULL in current implementation.
`...`	Additional parameters passed to parameterize function if parameters is NULL.