calc_krbc2pu: Back-calculates the Red Blood Cell to Unbound Plasma...

In httk: High-Throughput Toxicokinetics

Back-calculates the Red Blood Cell to Unbound Plasma Partition Coefficient

Description

Given an observed ratio of chemical concentration in blood to plasma, this function calculates a Red Blood Cell to unbound plasma (Krbc2pu) partition coefficient that would be consistent with that observation.

Usage

calc_krbc2pu(
  Rb2p,
  Funbound.plasma,
  hematocrit = NULL,
  default.to.human = FALSE,
  species = "Human",
  suppress.messages = TRUE
)

Arguments

Rb2p	The chemical blood:plasma concentration ratop
Funbound.plasma	The free fraction of chemical in the presence of plasma protein Rblood2plasma.
hematocrit	Overwrites default hematocrit value in calculating Rblood2plasma.
default.to.human	Substitutes missing animal values with human values if true.
species	Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").
suppress.messages	Determine whether to display certain usage feedback.

Value

The red blood cell to unbound chemical in plasma partition coefficient.

Author(s)

John Wambaugh and Robert Pearce

References

Pearce, Robert G., et al. "Evaluation and calibration of high-throughput predictions of chemical distribution to tissues." Journal of pharmacokinetics and pharmacodynamics 44.6 (2017): 549-565.

Ruark, Christopher D., et al. "Predicting passive and active tissue: plasma partition coefficients: interindividual and interspecies variability." Journal of pharmaceutical sciences 103.7 (2014): 2189-2198.

httk documentation built on Sept. 11, 2024, 9:32 p.m.