nutrimouse: Nutrimouse Dataset
In mixOmics: Omics Data Integration Project

Description Usage Format Details Source References

The nutrimouse dataset contains the expression measure of 120 genes potentially involved in nutritional problems and the concentrations of 21 hepatic fatty acids for forty mice.

1	data(nutrimouse)

A list containing the following components:

gene: data frame with 40 observations on 120 numerical variables.
lipid: data frame with 40 observations on 21 numerical variables.
diet: factor of 5 levels containing 40 labels for the diet factor.
genotype: factor of 2 levels containing 40 labels for the diet factor.

The data sets come from a nutrigenomic study in the mouse (Martin et al., 2007) in which the effects of five regimens with contrasted fatty acid compositions on liver lipids and hepatic gene expression in mice were considered. Two sets of variables were acquired on forty mice:

gene: expressions of 120 genes measured in liver cells, selected (among about 30,000) as potentially relevant in the context of the nutrition study. These expressions come from a nylon macroarray with radioactive labelling;
lipid: concentrations (in percentages) of 21 hepatic fatty acids measured by gas chromatography.

Biological units (mice) were cross-classified according to two factors experimental design (4 replicates):

Genotype: 2-levels factor, wild-type (WT) and PPARα -/- (PPAR).
Diet: 5-levels factor. Oils used for experimental diets preparation were corn and colza oils (50/50) for a reference diet (REF), hydrogenated coconut oil for a saturated fatty acid diet (COC), sunflower oil for an Omega6 fatty acid-rich diet (SUN), linseed oil for an Omega3-rich diet (LIN) and corn/colza/enriched fish oils for the FISH diet (43/43/14).

The nutrimouse dataset was provided by Pascal Martin from the Toxicology and Pharmacology Laboratory, National Institute for Agronomic Research, French.

Martin, P. G. P., Guillou, H., Lasserre, F., Déjean, S., Lan, A., Pascussi, J.-M., San Cristobal, M., Legrand, P., Besse, P. and Pineau, T. (2007). Novel aspects of PPARα-mediated regulation of lipid and xenobiotic metabolism revealed through a multrigenomic study. Hepatology 54, 767-777.

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