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#' Calculate effect of arbitrary complex interventions in component
#' network meta-analysis
#'
#' @description
#' Calculate effect of arbitrary complex interventions (i.e.,
#' combinations of several components) in component network
#' meta-analysis.
#'
#' @param x An object of class \code{netcomb} or \code{netcomplex}
#' (print function).
#' @param complex A matrix, vector or single numeric defining the
#' complex intervention(s) (see Details).
#' @param common A logical indicating whether results for common
#' effects model should be conducted.
#' @param random A logical indicating whether results for random
#' effects model should be conducted.
#' @param level The level used to calculate confidence intervals for
#' combinations of components.
#' @param nchar.comps A numeric defining the minimum number of
#' characters used to create unique names for components (see
#' Details).
#' @param backtransf A logical indicating whether printed results
#' should be back transformed. If \code{backtransf=TRUE}, results
#' for \code{sm="OR"} are printed as odds ratios rather than log
#' odds ratios.
#' @param digits Minimal number of significant digits, see
#' \code{print.default}.
#' @param digits.stat Minimal number of significant digits for z-value
#' of test for overall effect, see \code{print.default}.
#' @param digits.pval Minimal number of significant digits for
#' p-values, see \code{print.default}.
#' @param scientific.pval A logical specifying whether p-values should
#' be printed in scientific notation, e.g., 1.2345e-01 instead of
#' 0.12345.
#' @param zero.pval A logical specifying whether p-values should be
#' printed with a leading zero.
#' @param JAMA.pval A logical specifying whether p-values for test of
#' combination effect should be printed according to JAMA reporting
#' standards.
#' @param big.mark A character used as thousands separator.
#' @param legend A logical indicating whether a legend should be
#' printed.
#' @param warn.deprecated A logical indicating whether warnings should
#' be printed if deprecated arguments are used.
#' @param \dots Additional arguments (to catch deprecated arguments).
#'
#' @details
#' R functions \code{\link{netcomb}} and \code{\link{discomb}} only
#' report results for complex interventions present in the
#' network. This function can be used to calculate the effect for
#' arbitrary complex interventions.
#'
#' Complex interventions can be specified using argument \code{complex}:
#' \itemize{
#' \item a character vector with definition of complex interventions,
#' \item a single numeric defining the number of components to combine
#' in a complex intervention,
#' \item a dedicated C matrix.
#' }
#' In order to calculate effects of arbitrary complex interventions, a
#' C matrix is needed which describes how the complex interventions
#' are composed by the components (Rücker et al., 2020, Section
#' 3.2). The C matrix is constructed internally if not provided by
#' argument \code{complex}. All complex interventions occuring in the
#' network are considered if argument \code{complex} is missing.
#'
#' By default, component names are not abbreviated in
#' printouts. However, in order to get more concise printouts,
#' argument \code{nchar.comps} can be used to define the minimum
#' number of characters for abbreviated component names (see
#' \code{\link{abbreviate}}, argument \code{minlength}). R function
#' \code{\link{treats}} is utilised internally to create abbreviated
#' component names.
#'
#' @note
#' R function \code{\link{netcomparison}} can be used to calculate the
#' effect for comparisons of two arbitrary complex intervention in a
#' component network meta-analysis.
#'
#' @return
#' A list is returned by the function \code{netcomplex} with the
#' following elements:
#' \item{complex}{Complex intervention(s).}
#' \item{Comb.common, Comb.random}{A vector of combination effects
#' (common and random effects model).}
#' \item{seComb.common, seComb.random}{A vector with corresponding
#' standard errors (common and random effects model).}
#' \item{lower.Comb.common, lower.Comb.random}{A vector with lower
#' confidence limits for combinations (common and random effects
#' model).}
#' \item{upper.Comb.common, upper.Comb.random}{A vector with upper
#' confidence limits for combinations (common and random effects
#' model).}
#' \item{statistic.Comb.common, statistic.Comb.random}{A vector with
#' z-values for the overall effect of combinations (common and random
#' effects model).}
#' \item{pval.Comb.common, pval.Comb.random}{A vector with p-values for
#' the overall effect of combinations (common and random effects
#' model).}
#' \item{common, random}{A defined above.}
#' \item{level, nchar.comps, backtransf, x}{A defined above.}
#' \item{C.matrix}{C matrix.}
#'
#' @author Guido Schwarzer \email{guido.schwarzer@@uniklinik-freiburg.de}
#'
#' @seealso \code{\link{netcomb}}, \code{\link{discomb}},
#' \code{\link{netcomparison}}
#'
#' @references
#' Rücker G, Petropoulou M, Schwarzer G (2020):
#' Network meta-analysis of multicomponent interventions.
#' \emph{Biometrical Journal},
#' \bold{62}, 808--21
#'
#' @examples
#' data(Linde2016)
#'
#' # Only consider studies including Face-to-face PST (to reduce
#' # runtime of example)
#' #
#' face <- subset(Linde2016, id %in% c(16, 24, 49, 118))
#'
#' # Conduct random effects network meta-analysis
#' #
#' net1 <- netmeta(lnOR, selnOR, treat1, treat2, id,
#' data = face, ref = "placebo", sm = "OR", common = FALSE)
#'
#' # Additive model for treatment components (with placebo as inactive
#' # treatment)
#' #
#' nc1 <- netcomb(net1, inactive = "placebo")
#'
#' # Result for combination Face-to-face PST + SSRI
#' netcomplex(nc1, "Face-to-face PST + SSRI", nchar.comps = 4)
#' netcomplex(nc1, "F + S", nchar.comps = 4)
#'
#' # Result for combination Face-to-face PST + SSRI + Placebo
#' netcomplex(nc1, "Face-to-face PST + SSRI + Plac", nchar.comps = 4)
#'
#' \dontrun{
#' # Artificial example
#' t1 <- rep("A", 3)
#' t2 <- c("B+C", "A+C", "C+D")
#' TE <- c(0, 1, 0)
#' seTE <- rep(1, 3)
#' # Conduct (C)NMA
#' net2 <- netmeta(TE, seTE, t1, t2, random = FALSE)
#' nc2 <- netcomb(net2)
#'
#' # Result for combination A + B + C
#' netcomplex(nc2, "A + B + C")
#' # Same results
#' netcomplex(nc2, "A+B+C")
#' netcomplex(nc2, "B+C+A")
#' netcomplex(nc2, "C+B+A")
#' netcomplex(nc2, "c+b+a")
#'
#' # Generated C matrix
#' netcomplex(nc2, c(LETTERS[1:4], "A+B+C"))$C.matrix
#'
#' # Results for all possible combinations of two components
#' netcomplex(nc2, 2)
#' # Results for all possible combinations of three components
#' netcomplex(nc2, 3)
#' }
#'
#' @rdname netcomplex
#' @export
#' @export netcomplex
netcomplex <- function(x, complex,
common = x$common,
random = x$random,
level = x$level.ma,
nchar.comps = x$nchar.trts,
backtransf = x$backtransf,
warn.deprecated = gs("warn.deprecated"),
...) {
chkclass(x, "netcomb")
x <- updateversion(x)
##
args <- list(...)
chklogical(warn.deprecated)
common <- deprecated(common, missing(common), args, "fixed",
warn.deprecated)
chklogical(common)
##
chklogical(random)
chklevel(level)
##
nchar.comps <- replaceNULL(nchar.comps, 666)
chknumeric(nchar.comps, min = 1, length = 1)
##
chklogical(backtransf)
if (missing(complex)) {
complex <- x$trts
complex.orig <- complex
}
else
complex.orig <- complex
##
n.comps <- length(x$comps)
n.complex <- length(complex)
##
comps <- x$comps
add <- rep("", n.complex)
##
if (is.matrix(complex)) {
C.matrix <- complex
complex <- rownames(complex)
}
else if (is.numeric(complex)) {
chknumeric(complex, min = 1, max = n.comps, length = 1)
##
C.matrix <- createC(ncol = n.comps, ncomb = complex)
colnames(C.matrix) <- nam.comps <- x$comps
rownames(C.matrix) <- paste0("...", seq_len(nrow(C.matrix)))
##
for (i in seq_len(nrow(C.matrix))) {
rownames(C.matrix)[i] <-
paste(colnames(C.matrix[i, C.matrix[i, ] == 1, drop = FALSE]),
collapse = x$sep.comps)
}
##
complex <- rownames(C.matrix)
}
else if (is.vector(complex)) {
##
complex.list <- compsplit(complex, x$sep.comps)
##
comps.c <- setref(unique(unlist(complex.list)), c(comps, x$inactive),
error.text = "component names", length = 0)
##
complex.list <-
lapply(complex.list, setref, c(comps, x$inactive), length = 0)
##
complex.orig <- complex
##
add <- rep("", n.complex)
##
for (i in seq_len(n.complex)) {
add[i] <-
if (attr(compsplit(complex[i], x$sep.comps), "withspace")) " " else ""
complex[i] <-
paste(complex.list[[i]],
collapse = paste0(add[i], x$sep.comps, add[i]))
}
##
## Generate C matrix
##
C.matrix <- matrix(0, ncol = n.comps, nrow = n.complex)
colnames(C.matrix) <- x$comps
rownames(C.matrix) <- complex
##
for (i in seq_len(n.complex))
C.matrix[i, ] <- 1L * colnames(C.matrix) %in% complex.list[[i]]
}
else
stop("Argument 'complex' must be a single numeric, a matrix, or a vector.",
call. = FALSE)
##
## Calculate estimates for combinations
##
Comb.common <- as.vector(C.matrix %*% x$Comp.common)
seComb.common <-
sqrt(diag(C.matrix %*% x$Lplus.matrix.common %*% t(C.matrix)))
##
Comb.random <- as.vector(C.matrix %*% x$Comp.random)
seComb.random <-
sqrt(diag(C.matrix %*% x$Lplus.matrix.random %*% t(C.matrix)))
##
ci.f <- ci(Comb.common, seComb.common, level = level)
ci.r <- ci(Comb.random, seComb.random, level = level)
res <- list(complex = complex,
##
Comb.common = ci.f$TE,
seComb.common = ci.f$seTE,
lower.Comb.common = ci.f$lower,
upper.Comb.common = ci.f$upper,
statistic.Comb.common = ci.f$statistic,
pval.Comb.common = ci.f$p,
##
Comb.random = ci.r$TE,
seComb.random = ci.r$seTE,
lower.Comb.random = ci.r$lower,
upper.Comb.random = ci.r$upper,
statistic.Comb.random = ci.r$statistic,
pval.Comb.random = ci.r$p,
##
common = common,
random = random,
level = level,
##
C.matrix = C.matrix,
##
comps = colnames(C.matrix)[apply(C.matrix, 2, sum) > 0],
inactive = x$inactive,
nchar.comps = nchar.comps,
##
backtransf = backtransf,
##
x = x,
##
add = add,
##
complex.orig = complex.orig,
##
version = packageDescription("netmeta")$Version
)
##
## Backward compatibility
##
res$fixed <- res$common
##
res$Comb.fixed <- res$Comb.common
res$seComb.fixed <- res$seComb.common
res$lower.Comb.fixed <- res$lower.Comb.common
res$upper.Comb.fixed <- res$upper.Comb.common
res$statistic.Comb.fixed <- res$statistic.Comb.common
res$pval.Comb.fixed <- res$pval.Comb.common
##
class(res) <- c("netcomplex", class(res))
res
}
#' @rdname netcomplex
#' @method print netcomplex
#' @export
print.netcomplex <- function(x,
common = x$common,
random = x$random,
backtransf = x$backtransf,
nchar.comps = x$nchar.comps,
##
digits = gs("digits"),
digits.stat = gs("digits.stat"),
digits.pval = gs("digits.pval"),
##
scientific.pval = gs("scientific.pval"),
zero.pval = gs("zero.pval"),
JAMA.pval = gs("JAMA.pval"),
##
big.mark = gs("big.mark"),
##
legend = TRUE,
warn.deprecated = gs("warn.deprecated"),
##
...) {
chkclass(x, "netcomplex")
x <- updateversion(x)
##
args <- list(...)
chklogical(warn.deprecated)
common <- deprecated(common, missing(common), args, "fixed",
warn.deprecated)
chklogical(common)
##
chklogical(random)
chklogical(backtransf)
##
nchar.comps <- replaceNULL(nchar.comps, 666)
chknumeric(nchar.comps, min = 1, length = 1)
##
chknumeric(digits, min = 0, length = 1)
chknumeric(digits.stat, min = 0, length = 1)
chknumeric(digits.pval, min = 0, length = 1)
##
chklogical(scientific.pval)
chklogical(zero.pval)
chklogical(JAMA.pval)
##
chklogical(legend)
##
## Abbreviated component labels
##
n.complex <- length(x$complex)
complex <- rep("", n.complex)
##
if (common | random) {
comps <- c(x$comps, x$inactive)
comps.abbr <- treats(comps, nchar.comps)
##
for (i in seq_len(n.complex))
complex[i] <- compos(x$complex[i], comps, comps.abbr,
x$x$sep.comps, x$add[i] == " ")
}
sm <- x$x$sm
##
relative <- is.relative.effect(sm)
##
sm.lab <- sm
##
if (sm != "") {
sm.lab <- paste0("i", sm)
if (!backtransf & relative)
sm.lab <- paste0("log(", sm, ")")
}
##
ci.lab <- paste0(round(100 * x$level, 1), "%-CI")
if (common) {
Comb.common <- x$Comb.common
lower.Comb.common <- x$lower.Comb.common
upper.Comb.common <- x$upper.Comb.common
##
if (backtransf & relative) {
Comb.common <- exp(Comb.common)
lower.Comb.common <- exp(lower.Comb.common)
upper.Comb.common <- exp(upper.Comb.common)
}
}
##
if (random) {
Comb.random <- x$Comb.random
lower.Comb.random <- x$lower.Comb.random
upper.Comb.random <- x$upper.Comb.random
##
if (backtransf & relative) {
Comb.random <- exp(Comb.random)
lower.Comb.random <- exp(lower.Comb.random)
upper.Comb.random <- exp(upper.Comb.random)
}
}
if (common | random) {
##
if (is.numeric(x$complex.orig) & !is.matrix(x$complex.orig))
if (all(x$complex.orig == 1))
msg <- "Results for single components "
else {
if (x$complex.orig <= 10)
complex.orig <- c("two", "three", "four",
"five", "six", "seven", "eight", "nine",
"ten")[match(x$complex.orig, 2:10)]
else
complex.orig <- x$complex.orig
##
msg <- paste("Results for all possible combinations of",
complex.orig, "components\n")
}
else
msg <- "Results for combinations "
}
if (common) {
pval.f <- formatPT(x$pval.Comb.common, digits = digits.pval,
scientific = scientific.pval,
zero = zero.pval, JAMA = JAMA.pval,
lab.NA = "")
##
res.f <-
cbind(Comb = formatN(Comb.common, digits = digits,
"NA", big.mark = big.mark),
CI = formatCI(formatN(round(lower.Comb.common, digits),
digits, "NA",
big.mark = big.mark),
formatN(round(upper.Comb.common, digits),
digits, "NA",
big.mark = big.mark)),
zval = formatN(x$statistic.Comb.common, digits = digits.stat,
"NA", big.mark = big.mark),
pval = pval.f)
##
cat(msg)
##
dimnames(res.f)[[1]] <- complex
dimnames(res.f)[[2]] <- c(sm.lab, ci.lab, "z", "p-value")
##
cat("(additive CNMA model, common effects model):\n")
prmatrix(res.f, quote = FALSE, right = TRUE, na.print = "--")
##
if (random)
cat("\n")
}
if (random) {
##
pval.r <- formatPT(x$pval.Comb.random, digits = digits.pval,
scientific = scientific.pval,
zero = zero.pval, JAMA = JAMA.pval,
lab.NA = "")
##
res.r <-
cbind(Comb = formatN(Comb.random, digits = digits,
"NA", big.mark = big.mark),
CI = formatCI(formatN(round(lower.Comb.random, digits),
digits, "NA",
big.mark = big.mark),
formatN(round(upper.Comb.random, digits),
digits, "NA",
big.mark = big.mark)),
zval = formatN(x$statistic.Comb.random, digits = digits.stat,
"NA", big.mark = big.mark),
pval = pval.r)
##
dimnames(res.r)[[1]] <- complex
dimnames(res.r)[[2]] <- c(sm.lab, ci.lab, "z", "p-value")
##
cat(msg)
##
cat("(additive CNMA model, random effects model):\n")
prmatrix(res.r, quote = FALSE, right = TRUE, na.print = "--")
}
if (legend && (common | random)) {
diff.comps <- comps != comps.abbr
any.comps <- any()
##
if (any(diff.comps)) {
cat("\nLegend:\n")
##
tmat <- data.frame(comps.abbr, comps)
tmat <- tmat[diff.comps, ]
names(tmat) <- c("Abbreviation", " Component name")
tmat <- tmat[order(tmat$Abbreviation), ]
##
prmatrix(tmat, quote = FALSE, right = TRUE,
rowlab = rep("", length(comps.abbr)))
}
}
invisible(NULL)
}
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