blosum50: BLOSUM 50 substitution matrix

In peplib: Peptide Library Analysis Methods

Description

The BLOSUM 50 substitution matrix which may be used for calculating distances. This is for a more diverse library than BLOSUM 62.

Usage

data(blosum50)

Format

A matrix where element i,j represents how often homologous proteins have element i substituted with element j. Thus, it is a measure of similarity. Positive numbers indicate easy substitution, while negative numbers indicate difficult substitution.

Source

Henikoff, S.; Henikoff, J.G. (1992). "Amino Acid Substitution Matrices from Protein Blocks". PNAS 89 (22): 10915-10919. doi:10.1073/pnas.89.22.10915

Examples

data(blosum50)
##Change the normal distance parameters
default.MetricParams <-  new("MetricParams", smatrix=blosum50, gapOpen=-10, gapExtension=-0.2)
##Now calls to dist on sequences will use blosum 50 instead

peplib documentation built on May 29, 2017, 10:52 p.m.