NEWS.md

In tcgsaseq: Time-Course Gene Set Analysis for RNA-Seq Data

News about the tcgsaseq R package

Main changes in Version 2.0.1 (2020-09-09)

• renaming varseq() function into varcompseq (following trademark infringement notification from Golden Helix, Inc)
• indicating soft-deprecation of tcgsaseqin favor of the dearseq Bioconductor package

Main changes in Version 2.0.0 (2019-08-02):

• transform = TRUE is now the default
• loc-lin weights are now computed on unconditional (transformed) counts. They should be more robust this way to outlier genes

Main changes in Version 1.9.0 (2019-07-18):

• (partial) parallel support for permutations
• progressbar for permutations in interactive mode
• bug fix for voom-like weights

Main changes in Version 1.8.1 (2018-12-06):

• perm_pe function for exact p-values and accurate FDR control when using permutation test. The column names of the $pvals output are back to being the same regardless of the test chosen being asympotic or permutation
• dsFDR is not used anymore

Main changes in Version 1.8.0 (2018-11-23):

• dsFDR function for accurate discrete FDR control when using permutation test. This changes the column names of the $pvals output when which_test = permutations

Main changes in Version 1.7.2 (2018-07-18):

• faster permutations

Main changes in Version 1.7.1 (2018-07-07):

• faster implementation

Main changes in Version 1.6.5 (2017-12-24) --- this is only a minor release:

• bug fix in the log2-cpm transformation computation (for preprocessed = FALSE) in sp_weights
• bug fix in sp_weights when facing NA or NaNvalues

Main changes in Version 1.6.3 (2017-11-09)

• WARNING instead of ERROR when a gene set with no measured genes is tested
• NA support through na.rm_... logical arguments
• bug fix for row.names error in weights computation for gene-wise analysis

Main changes in Version 1.6.2 (2017-08-04)

• bug fix to the log2-cpm transformation computation (for preprocessed = FALSE)
• improvement to defaults in varseq and tcgsa_seq wrapper functions, including an option to compute heteroscedasticity weights without conditioning on the variable(s) to be tested

Main changes in Version 1.5.2 (2017-07-11)

• user-friendly wrapper function varseq for gene-wise testing
• RAM usage optimization

Main changes in Version 1.5.1 (2017-05-24) --- this is only a minor release:

• homogeneous test now available for gene-wise testing.

Main changes in Version 1.5.0 (2017-03-27):

• permutation test now available for gene-wise testing

Main changes in Version 1.4.0 (2017-02-21):

• bug fix for gene-wise testing

Main changes in Version 1.3.1 (2016-11-24):

• bug fix for testing several covariates together (such as several bases of time) which now gives correct p-values
• support for gene-wise testing
• example dataset 'baduel_small' was changed to 'baduel_5gs' which includes 1943 additional gene expressions and the definition of 5 gene sets
• documentation updated

Main changes in Version 1.2.0 (2016-07-19):

• support homogeneous gene set test
• documentation updated

Main changes in Version 1.1.0 (2016-05-26):

• improved imports
• documentation updated

Main changes in Version 1.0.2 (2016-05-18) --- this is only a minor release:

• documentation and CITATION updated

Main changes in Version 1.0.1 (2016-05-14) --- this is only a minor release:

• help file improvements

tcgsaseq documentation built on Sept. 13, 2020, 5:13 p.m.