stan_efftox_demo: Fit the EffTox model presented in Thall et al. (2014)

In trialr: Clinical Trial Designs in 'rstan'

Fit the EffTox model presented in Thall et al. (2014)

Description

Fit the EffTox model presented in Thall et al. (2014) using Stan for full Bayesian inference.

Usage

stan_efftox_demo(outcome_str, ...)

Arguments

outcome_str	A string representing the outcomes observed hitherto. See efftox_parse_outcomes for a description of syntax and examples. Alternatively, you may provide doses_given, eff and tox parameters. See Details.
...	Extra parameters are passed to rstan::sampling. Commonly used options are iter, chains, warmup, cores, control. sampling.

Value

An object of class efftox_fit

Author(s)

Kristian Brock [e-mail]

References

Thall, P., & Cook, J. (2004). Dose-Finding Based on Efficacy-Toxicity Trade-Offs. Biometrics, 60(3), 684-693.

Thall, P., Herrick, R., Nguyen, H., Venier, J., & Norris, J. (2014). Effective sample size for computing prior hyperparameters in Bayesian phase I-II dose-finding. Clinical Trials, 11(6), 657-666. https://doi.org/10.1177/1740774514547397

Brock, K., Billingham, L., Copland, M., Siddique, S., Sirovica, M., & Yap, C. (2017). Implementing the EffTox dose-finding design in the Matchpoint trial. BMC Medical Research Methodology, 17(1), 112. https://doi.org/10.1186/s12874-017-0381-x

See Also

efftox_fit stan_efftox

Examples

## Not run: 
# This model is presented in Thall et al. (2014)
mod2 <- stan_efftox_demo('1N 2E 3B', seed = 123)

# The seed is passed to the Stan sampler. The usual Stan sampler params like
# cores, iter, chains etc are passed on too via the ellipsis operator.

## End(Not run)

trialr documentation built on April 1, 2023, 12:03 a.m.