Get_Fibonacci: Get 'modified Finonacci' sequence for Phase I design

In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs

Get 'modified Finonacci' sequence for Phase I design

Description

Get 'modified Finonacci' sequence for Phase I design Other decreasing step schemes can be specified

Usage

Get_Fibonacci(
  Ndose,
  first_dose,
  fibonacci = c(1, 2, 1.67, 1.5, rep(1.33, Ndose - 4))
)

Arguments

Ndose	number of dose levels
first_dose	First dose level
fibonacci	decreasing step scheme, default is c(1,2,1.67,1.5,rep(1.33,Ndose-4)

Value

a data.frame with elements

• dose_level: dose level

• dose: actual dose to be used

• incr_ratio: The ratio of successive doses

References

Penel N, Kramar A. What does a modified-Fibonacci dose-escalation

Examples

Fibonacci<-Get_Fibonacci(Ndose=6,first_dose=0.0017)

IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.