get_Table_rules: Get table with summary of decision rules for phase I design

In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs

Get table with summary of decision rules for phase I design

Description

Get table with summary of decision rules for phase I design (BOIN, Keyboard or i3+3 design)

Usage

get_Table_rules(
  N,
  phi,
  phi1 = NULL,
  phi2 = NULL,
  maxtox,
  halfkey = NULL,
  design
)

Arguments

N	sample size
phi	target toxicity rate
phi1	the highest DLT rate that is deemed subtherapeutic (i.e., underdosing), such that dose escalation should be made
phi2	the lowest DLT rate that is deemed overly toxic (i.e., overdosing), such that dose de-escalation is required
maxtox	P(DLT rate>phi|c,n)<=maxtox as value for maxprob in get_Elim_rules
halfkey	half length of key in keyboard design
design	"BOIN" or "Keyboard" or "i3+3"

Value

a data.frame with elements

• n: number of patients

• E: max(observed DLTs) at n –> decision to escalate dose

• R: range(observed DLTs) at n –> decision to retain dose

• R: range(observed DLTs) at n –> decision to retain dose

• lambda_e: if observed DLT rate<= lambda_e –> dose escalation

• lambda_d: if observed DLT rate>= lambda_d –> dose de-escalation

References

Liu S, Yuan Y. Bayesian Optimal Interval Designs for Phase I Clinical Trials. J R Stat Soc Ser C Appl Stat. 2015;64:507–23

Examples

BOIN_table<-get_Table_rules(N=21,phi=0.3,phi1=0.6*0.3,phi2=1.4*0.3,maxtox=0.95,design="BOIN")
KEYB_table<-get_Table_rules(N=21,phi=0.3,maxtox=0.95,halfkey=0.05,design="Keyboard")
i33_table<-get_Table_rules(N=21,phi=0.3,phi1=0.6*0.3,phi2=1.4*0.3,maxtox=0.95,design="i3+3")

IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.