ph1_sim_OC_plot: Plot operating characteristics of phase 1 design

In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs

Plot operating characteristics of phase 1 design

Description

Plot operating characteristics of phase 1 design. First design is "blue", second one"red", and third one "darkgreen"

Usage

ph1_sim_OC_plot(
  ph1_sim_OC_output,
  ylim_N,
  save_as,
  outcomes = c(3:17),
  layout = c(5, 3),
  linecol,
  title
)

Arguments

ph1_sim_OC_output	list of output objects of ph1_sim_OC
ylim_N	max N for plots with number of patients (typically max sample size of 3+3 design)
save_as	where to save output
outcomes	select outcomes from ph1_sim_OC_output (item 2)
layout	layout for panel of plots, default is c(5,3) for 15 outcomes (default for 'outcomes' parameter)
linecol	vector of line colors for plot. Needs to have same length as ph1_sim_OC_output
title	add title to plot

Value

plot

Examples

## Not run: 
BOIN<-ph1_sim_OC(nsim=10, scenarios=list(c(0.40 ,0.50 ,0.60 ,0.70 ,0.80 ,0.90),
                                         c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ,0.80),
                                         c(0.30 ,0.35 ,0.40 ,0.60 ,0.75 ,0.90),
                                         c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ,0.70),
                                         c(0.20 ,0.30 ,0.50 ,0.65 ,0.80 ,0.90),
                                         c(0.20 ,0.25 ,0.30 ,0.40 ,0.60 ,0.75),
                                         c(0.10 ,0.20 ,0.30 ,0.40 ,0.50 ,0.60),
                                         c(0.10 ,0.15 ,0.25 ,0.30 ,0.50 ,0.75),
                                         c(0.05 ,0.10 ,0.15 ,0.20 ,0.25 ,0.30),
                                         c(0.05 ,0.10 ,0.20 ,0.30 ,0.50 ,0.65),
                                         c(0.025,0.05 ,0.10 ,0.20 ,0.30 ,0.40)), 
                 phi=0.3, phi1=0.6*0.3, phi2=1.4*0.3, maxtox=0.95, N=18, 
                 cohortsize=3, maxNretain=9, acc_tit=0, design="BOIN", MTD_safer=TRUE)

three<-ph1_sim_OC(nsim=10, scenarios=list(c(0.40 ,0.50 ,0.60 ,0.70 ,0.80 ,0.90),
                                          c(0.30 ,0.40 ,0.50 ,0.60 ,0.70 ,0.80),
                                          c(0.30 ,0.35 ,0.40 ,0.60 ,0.75 ,0.90),
                                          c(0.20 ,0.30 ,0.40 ,0.50 ,0.60 ,0.70),
                                          c(0.20 ,0.30 ,0.50 ,0.65 ,0.80 ,0.90),
                                          c(0.20 ,0.25 ,0.30 ,0.40 ,0.60 ,0.75),
                                          c(0.10 ,0.20 ,0.30 ,0.40 ,0.50 ,0.60),
                                          c(0.10 ,0.15 ,0.25 ,0.30 ,0.50 ,0.75),
                                          c(0.05 ,0.10 ,0.15 ,0.20 ,0.25 ,0.30),
                                          c(0.05 ,0.10 ,0.20 ,0.30 ,0.50 ,0.65),
                                          c(0.025,0.05 ,0.10 ,0.20 ,0.30 ,0.40)), 
               phi=0.3, design="3+3",acc_tit=1)
ph1_sim_OC_plot(ph1_sim_OC_output=list(BOIN,three), 
ylim_N=36,save_as="C:/Users/kdhollander/Desktop/test", outcomes=c(3:17), 
linecol=c("blue","red"),title="Test")

## End(Not run)

IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.