get_Elim_rules: Get dose elimination rules for phase I design

In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs

Get dose elimination rules for phase I design

Description

Get Dose elimination rules for phase I design, based on Bayesian posterior probability

Usage

get_Elim_rules(Nmax, phi, maxprob)

Arguments

Nmax	maximum number of patients
phi	target DLT rate
maxprob	P(DLT rate>phi|c,n)<=maxprob

Details

A uniform Beta(1,1) prior is used to calculate the posterior Bayesian probability

Value

a data.frame with elements

• phi: target toxicity rate

• n: number of patients at which toxicity is evaluated

• c: max number of DLTs at which P(DLT rate>phi)<=maxprob

• c_STOP: c+1, i.e. min number of DLTs at which P(DLT rate>phi|c_STOP,n)>maxprob

• prob_Bayes: P(DLT rate>phi|c,n)

• prob_Obs: c/n or the allowed observed toxicity rate with no stopping

Examples

rule<-get_Elim_rules(Nmax=21,phi=0.3,maxprob=0.95)

IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.