get_BOIN_rules: Get BOIN decision rules for phase I design

In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs

Get BOIN decision rules for phase I design

Description

Get BOIN decision rules for phase I design

Usage

get_BOIN_rules(phi, phi1, phi2)

Arguments

phi	target toxicity rate
phi1	the highest DLT rate that is deemed subtherapeutic (i.e., underdosing), such that dose escalation should be made
phi2	the lowest DLT rate that is deemed overly toxic (i.e., overdosing), such that dose de-escalation is required

Value

a data.frame with elements

• phi

• phi1

• phi2

• lambda_e: if observed DLT rate<= lambda_e –> dose escalation

• lambda_d: if observed DLT rate>= lambda_d –> dose de-escalation

References

Liu S, Yuan Y. Bayesian Optimal Interval Designs for Phase I Clinical Trials. J R Stat Soc Ser C Appl Stat. 2015;64:507–23

Examples

rule<-get_BOIN_rules(phi=0.3,phi1=0.6*0.3,phi2=1.4*0.3)

IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.