get_i33_rules: Get i3+3 decision rules for phase I design

In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs

Get i3+3 decision rules for phase I design

Description

Get i3+3 decision rules for phase I design

Usage

get_i33_rules(N, phi, phi1, phi2)

Arguments

N	sample size
phi	target toxicity rate
phi1	the highest DLT rate that is deemed subtherapeutic (i.e., underdosing), such that dose escalation should be made
phi2	the lowest DLT rate that is deemed overly toxic (i.e., overdosing), such that dose de-escalation is required

Value

a data.frame with elements

• n: number of patients

• x: observed DLTs

• decision: "E" (escalate),"R" (retain) or "D" (de-escalate)

References

Liu M et al. The i3+3 design for phase I clinical trials. Journal of Biopharmaceutical Statistics 2020;30:294-304

Examples

rule<-get_i33_rules(N=6,phi=0.3,phi1=0.25,phi2=0.35)

IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.