get_Keyboard_rules: Get Keyboard decision rules for phase I design
In IDDI-BE/PhIdesign: Decision rules and simulation of model-assisted Phase I designs
View source: R/get_Keyboard_rules.R
get_Keyboard_rules R Documentation
Get Keyboard decision rules for phase I design
Description
Get Keyboard decision rules for phase I design
Usage
get_Keyboard_rules(N, phi, halfkey)
Arguments
N
sample size
phi
target toxicity rate
halfkey
half length of key in keyboard design
Details
A uniform Beta(1,1) prior is used to calculate the posterior Bayesian probability for each 'key'
Value
a data.frame with elements
n: number of patients
x: observed DLTs
decision: "E" (escalate),"R" (retain) or "D" (de-escalate)
References
Yan F, Mandrekar SJ, Yuan Y. Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials. Clin Cancer Res. 2017; 23: 3994–4003
Examples
Keyboard_rules <- get_Keyboard_rules(N=9,phi=0.3,halfkey=0.05)
IDDI-BE/PhIdesign documentation built on Feb. 7, 2024, 9:32 p.m.
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View source: R/get_Keyboard_rules.R
| get_Keyboard_rules | R Documentation |
Get Keyboard decision rules for phase I design
Description
Get Keyboard decision rules for phase I design
Usage
get_Keyboard_rules(N, phi, halfkey)
Arguments
N |
sample size |
phi |
target toxicity rate |
halfkey |
half length of key in keyboard design |
Details
A uniform Beta(1,1) prior is used to calculate the posterior Bayesian probability for each 'key'
Value
a data.frame with elements
n: number of patients
x: observed DLTs
decision: "E" (escalate),"R" (retain) or "D" (de-escalate)
References
Yan F, Mandrekar SJ, Yuan Y. Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials. Clin Cancer Res. 2017; 23: 3994–4003
Examples
Keyboard_rules <- get_Keyboard_rules(N=9,phi=0.3,halfkey=0.05)
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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