mr_egger_regression_bootstrap: Run bootstrap to generate standard errors for MR

In MRCIEU/TwoSampleMR: Two Sample MR Functions and Interface to MR Base Database

Run bootstrap to generate standard errors for MR

Description

Run bootstrap to generate standard errors for MR

Usage

mr_egger_regression_bootstrap(b_exp, b_out, se_exp, se_out, parameters)

Arguments

b_exp	Vector of genetic effects on exposure.
b_out	Vector of genetic effects on outcome.
se_exp	Standard errors of genetic effects on exposure.
se_out	Standard errors of genetic effects on outcome.
parameters	List of parameters. Specifically, the nboot parameter can be specified for the number of bootstrap replications. The default is parameters=list(nboot=1000).

Value

List of with the following elements:

b

MR estimate

se

Standard error of MR estimate

pval

p-value of MR estimate

b_i

Estimate of horizontal pleiotropy (intercept)

se_i

Standard error of intercept

pval_i

p-value of intercept

mod

Summary of regression

dat

Original data used for MR Egger regression

MRCIEU/TwoSampleMR documentation built on Sept. 28, 2024, 6:51 p.m.