mr_penalised_weighted_median: Penalised weighted median MR

In MRCIEU/TwoSampleMR: Two Sample MR Functions and Interface to MR Base Database

Penalised weighted median MR

Description

Modification to standard weighted median MR Updated based on Burgess 2016 "Robust instrumental variable methods using multiple candidate instruments with application to Mendelian randomization"

Usage

mr_penalised_weighted_median(
  b_exp,
  b_out,
  se_exp,
  se_out,
  parameters = default_parameters()
)

Arguments

b_exp	Vector of genetic effects on exposure
b_out	Vector of genetic effects on outcome
se_exp	Standard errors of genetic effects on exposure
se_out	Standard errors of genetic effects on outcome
parameters	List containing penk - Constant term in penalisation, and nboot - number of bootstrap replications to calculate SE. default_parameters() sets parameters=list(penk=20, nboot=1000).

Value

List with the following elements:

b

MR estimate

se

Standard error

pval

p-value

MRCIEU/TwoSampleMR documentation built on Sept. 28, 2024, 6:51 p.m.