mv_multiple: Perform IVW multivariable MR

In MRCIEU/TwoSampleMR: Two Sample MR Functions and Interface to MR Base Database

Perform IVW multivariable MR

Description

Performs modified multivariable MR analysis. For each exposure the instruments are selected then all exposures for those SNPs are regressed against the outcome together, weighting for the inverse variance of the outcome.

Usage

mv_multiple(
  mvdat,
  intercept = FALSE,
  instrument_specific = FALSE,
  pval_threshold = 5e-08,
  plots = FALSE
)

Arguments

mvdat	Output from mv_harmonise_data().
intercept	Should the intercept by estimated (TRUE) or force line through the origin (FALSE, default).
instrument_specific	Should the estimate for each exposure be obtained by using all instruments from all exposures (FALSE, default) or by using only the instruments specific to each exposure (TRUE).
pval_threshold	P-value threshold to include instruments. The default is 5e-8.
plots	Create plots? The default is FALSE.

Value

List of results

MRCIEU/TwoSampleMR documentation built on Sept. 28, 2024, 6:51 p.m.