mv_multiple: Perform IVW multivariable MR
In MRCIEU/TwoSampleMR: Two Sample MR Functions and Interface to MR Base Database

mv_multiple

R Documentation

Perform IVW multivariable MR

Description

Performs modified multivariable MR analysis. For each exposure the instruments are selected then all exposures for those SNPs are regressed against the outcome together, weighting for the inverse variance of the outcome.

Usage

mv_multiple(
  mvdat,
  intercept = FALSE,
  instrument_specific = FALSE,
  pval_threshold = 5e-08,
  plots = FALSE
)

Arguments

`mvdat`	Output from `mv_harmonise_data()`.
`intercept`	Should the intercept by estimated (`TRUE`) or force line through the origin (`FALSE`, default).
`instrument_specific`	Should the estimate for each exposure be obtained by using all instruments from all exposures (`FALSE`, default) or by using only the instruments specific to each exposure (`TRUE`).
`pval_threshold`	P-value threshold to include instruments. The default is `5e-8`.
`plots`	Create plots? The default is `FALSE`.