Set of tools for evaluating pooled high-throughput screening experiments, typically employing CRISPR/Cas9 or shRNA expression cassettes. Contains methods for interrogating library and cassette behavior within an experiment, identifying differentially abundant cassettes, aggregating signals to identify candidate targets for empirical validation, hypothesis testing, and comprehensive reporting. Version 2.0 extends these applications to include a variety of tools for contextualizing and integrating signals across many experiments, incorporates extended signal enrichment methodologies via the "sparrow" package, and streamlines many formal requirements to aid in interpretablity.
|Author||Russell Bainer, Dariusz Ratman, Steve Lianoglou, Peter Haverty|
|Bioconductor views||BiomedicalInformatics CRISPR CellBiology DifferentialExpression ExperimentalDesign FunctionalGenomics GeneSetEnrichment Genetics ImmunoOncology MultipleComparison Normalization Pharmacogenetics Pharmacogenomics PooledScreens Preprocessing QualityControl RNASeq Regression Software SystemsBiology Visualization|
|Maintainer||Russell Bainer <email@example.com>|
|Package repository||View on GitHub|
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