View source: R/functions_multitrial.R
Epgo23 | R Documentation |
In the setting of Case 2: Strategy 2/2( + 1); at least two trials significant (and the treatment effect of the other one at least showing in the same direction) this function calculates the probability that a third phase III trial is necessary.
Epgo23(HRgo, d2, alpha, beta, w, hr1, hr2, id1, id2)
HRgo |
threshold value for the go/no-go decision rule |
d2 |
total number of events in phase II |
alpha |
significance level |
beta |
|
w |
weight for mixture prior distribution |
hr1 |
first assumed true treatment effect on HR scale for prior distribution |
hr2 |
second assumed true treatment effect on HR scale for prior distribution |
id1 |
amount of information for |
id2 |
amount of information for |
The output of the function Epgo23()
is the probability to a third phase III trial.
res <- Epgo23(HRgo = 0.8, d2 = 50, w = 0.3, alpha = 0.025, beta = 0.1,
hr1 = 0.69, hr2 = 0.81, id1 = 280, id2 = 420)
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